Evidence map›Paper›PMID 28322352›Full record

ArticleScientific reports2017

Gene-based genome-wide association study identified 19p13.3 for lean body mass.

Shu Ran, Lei Zhang, Lu Liu, An-Ping Feng, Yu-Fang Pei, Lei Zhang, Ying-Ying Han, Yong Lin, Xiao Li, Wei-Wen Kong and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 2 countries.

Shu RanCenter of System Biomedical Sciences, University of Shanghai for Science and Technology, Shanghai, PR China.
Lei ZhangCenter for Genetic Epidemiology and Genomics, School of Public Health, Soochow University, Jiangsu, PR China.
Lu LiuCenter for Genetic Epidemiology and Genomics, School of Public Health, Soochow University, Jiangsu, PR China.
An-Ping FengCenter for Genetic Epidemiology and Genomics, School of Public Health, Soochow University, Jiangsu, PR China.
Yu-Fang PeiJiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Soochow University, Jiangsu, PR China.
Lei ZhangCenter of System Biomedical Sciences, University of Shanghai for Science and Technology, Shanghai, PR China.
Ying-Ying HanCenter of System Biomedical Sciences, University of Shanghai for Science and Technology, Shanghai, PR China.
Yong LinCenter of System Biomedical Sciences, University of Shanghai for Science and Technology, Shanghai, PR China.
Xiao LiCenter for Genetic Epidemiology and Genomics, School of Public Health, Soochow University, Jiangsu, PR China.
Wei-Wen KongCenter for Genetic Epidemiology and Genomics, School of Public Health, Soochow University, Jiangsu, PR China.
Xin-Yi YouCenter for Genetic Epidemiology and Genomics, School of Public Health, Soochow University, Jiangsu, PR China.
Wen ZhaoCenter for Genetic Epidemiology and Genomics, School of Public Health, Soochow University, Jiangsu, PR China.
Qing TianDepartment of Biostatistics, Tulane University, New Orleans, Louisiana, USA.
Hui ShenDepartment of Biostatistics, Tulane University, New Orleans, Louisiana, USA.
Yong-Hong ZhangJiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Soochow University, Jiangsu, PR China.
Hong-Wen DengCenter of System Biomedical Sciences, University of Shanghai for Science and Technology, Shanghai, PR China.
Soochow University · CNUniversity of Shanghai for Science and Technology · CNTulane University · US

Funding

Tulane COBRE in Cardiometabolic Diseases Clinical Research CoreP20GM109036 · NIGMS · TULANE UNIVERSITY OF LOUISIANA · PI JING CHEN · 2016 to 2026
$25.3M
Proteome-wide Expression Study of Osteogenic CellsP50AR055081 · NIAMS · UNIVERSITY OF MISSOURI KANSAS CITY · PI DENG, HONG-WEN · 2007 to 2012
$5.0M
ROBUST AND POWERFUL TEST OF CANDIDATE GENES TO BONE MASSR01AR050496 · NIAMS · UNIVERSITY OF MISSOURI KANSAS CITY · PI DENG, HONG-WEN · 2004 to 2013
$3.8M
Identification of Proteins Important for Male OsteoporosisR01AR057049 · NIAMS · UNIVERSITY OF MISSOURI KANSAS CITY · PI DENG, HONG-WEN · 2009 to 2013
$2.4M
Genomic search for bone mass QTLsR01AG026564 · NIA · UNIVERSITY OF MISSOURI KANSAS CITY · PI DENG, HONG-WEN · 2007 to 2010
$2.3M
Genome-wide association study of periodontitisRC2DE020756 · NIDCR · UNIVERSITY OF MISSOURI KANSAS CITY · PI DENG, HONG-WEN, GENCO, ROBERT J · 2009 to 2009
$173k
Genetics of Osteoporotic Fractures in ChineseR03TW008221 · FIC · UNIVERSITY OF MISSOURI KANSAS CITY · PI DENG, HONG-WEN · 2009 to 2011
$171k
FIC NIH HHS R03 TW008221NIAMS NIH HHS P50 AR055081NIAMS NIH HHS R01 AR050496NIAMS NIH HHS R01 AR057049NIA NIH HHS R01 AG026564NIDCR NIH HHS RC2 DE020756NIGMS NIH HHS P20 GM109036
6 · The paper itself

Abstract

Lean body mass (LBM) is a complex trait for human health. To identify genomic loci underlying LBM, we performed a gene-based genome-wide association study of lean mass index (LMI) in 1000 unrelated Caucasian subjects, and replicated in 2283 unrelated Caucasians subjects. Gene-based association analyses highlighted the significant associations of three genes UQCR, TCF3 and MBD3 in one single locus 19p13.3 (discovery p = 6.10 × 10

Indexed as

Chromosome MappingChromosomes, Human, Pair 19Genome-Wide Association StudyAdultAgedBody CompositionFemaleGenotypeHumansMaleMiddle AgedPhenotypePolymorphism, Single NucleotideThinness

Identifiers

PMID28322352
PMCPMC5359571
OpenAlexW2600609697

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.