ArticleScientific reports2017
The epidemic dynamics of hepatitis C virus subtypes 4a and 4d in Saudi Arabia.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Phylodynamics of HIV in the Mexico City Metropolitan Region.Journal of virology · 2022Article
- Assessing the impact of COVID-19 border restrictions on dengue transmission in Yunnan Province, China: an observational epidemiological and phylogenetic analysis.The Lancet regional health. Western Pacific · 2021Article
- Non-epidemic HCV genotypes in low- and middle-income countries and the risk of resistance to current direct-acting antiviral regimens.Journal of hepatology · 2021Review
- Distribution of hepatitis C virus (HCV) genotypes in a Saudi Arabian hospital during the 2015-2020 period.Le infezioni in medicina · 2021Article
- Comparative Circulation Dynamics of the Five Main HIV Types in China.Journal of virology · 2020Article
- Online Bayesian Phylodynamic Inference in BEAST with Application to Epidemic Reconstruction.Molecular biology and evolution · 2020Article
- Article
- Hepatitis C virus genotype 1 and 2 recombinant genomes and the phylogeographic history of the 2k/1b lineage.Virus evolution · 2019Article
- Article
- Increasing importance of European lineages in seeding the hepatitis C virus subtype 1a epidemic in Spain.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2019Article
- The effects of random taxa sampling schemes in Bayesian virus phylogeography.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2018Article
- Epidemic history of hepatitis C virus genotypes and subtypes in Portugal.Scientific reports · 2018Article
- On the importance of negative controls in viral landscape phylogeography.Virus evolution · 2018Article
- Relapse or reinfection after failing hepatitis C direct acting antiviral treatment: Unravelled by phylogenetic analysis.PloS one · 2018Article
- Hepatitis C virus genotypes in Saudi Arabia: a future prediction and laboratory profile.Virology journal · 2017Article
- Accurate quantification of within- and between-host HBV evolutionary rates requires explicit transmission chain modelling.Virus evolution · 2017Article
- Cross-border spread, lineage displacement and evolutionary rate estimation of rabies virus in Yunnan Province, China.Virology journal · 2017Article
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Authors and funding
12 authors.
Funding
Abstract
The relatedness between viral variants sampled at different locations through time can provide information pertinent to public health that cannot readily be obtained through standard surveillance methods. Here, we use virus genetic data to identify the transmission dynamics that drive the hepatitis C virus subtypes 4a (HCV4a) and 4d (HCV4d) epidemics in Saudi Arabia. We use a comprehensive dataset of newly generated and publicly available sequence data to infer the HCV4a and HCV4d evolutionary histories in a Bayesian statistical framework. We also introduce a novel analytical method for an objective assessment of the migration intensity between locations. We find that international host mobility patterns dominate over within country spread in shaping the Saudi Arabia HCV4a epidemic, while this may be different for the HCV4d epidemic. This indicates that the subtypes 4a and 4d burden can be most effectively reduced by combining the prioritized screening and treatment of Egyptian immigrants with domestic prevention campaigns. Our results highlight that the joint investigation of evolutionary and epidemiological processes can provide valuable public health information, even in the absence of extensive metadata information.
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