ArticleScientific reports2017
Tea polyphenols inhibit the growth and virulence properties of Fusobacterium nucleatum.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
What it found
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Who cites it
58 citing papers in PubMed, 113 citations in OpenAlex.
- Green tea and hyaluronic acid gel enhance fibroblast activation and improves the gingival healing post-third molar extraction.Scientific reports · 2024Trial
- In Vitro Modulatory Effect of Stimulant Beverages on the Growth Kinetics of Intestinal Bacteria Associated with Colorectal Cancer.Foods (Basel, Switzerland) · 2026Article
- Beneficial effects of dietary green tea extract supplementation during necrotic enteritis challenge in broiler chicks.Poultry science · 2026Article
- Nutrition as Modulator of Oxidative Stress in Cancer Prevention and Treatment.International journal of molecular sciences · 2026Review
- Phytochemicals remodel antitumor immunity via the "microbiota-metabolite-receptor" axis: focus on colorectal cancer and immunotherapy.Medical oncology (Northwood, London, England) · 2026Review
- Natural 2-phenyl chroman flavonoids against Streptococcus mutans: prospects of herbal remedies for dental caries.Journal of materials science. Materials in medicine · 2026Review
- The Role ofBiomedicines · 2026Review
- [Research Advances on Natural Products in Maintaining Oral Microecological Balance].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026Review
- A Review of the Impact of Green Tea (Current pharmaceutical design · 2026Review
- Crosstalk between iron metabolism dysregulation and the oral microbiome in periodontitis.Journal of oral microbiology · 2026Review
- Progress on the regulation of colorectal cancer and cardio-oncology by the gut microbiota and nutrients.Frontiers in immunology · 2026Review
- Review
- Targeting Fusobacterium nucleatum in colorectal cancer: therapeutic strategies and future directions.Infectious agents and cancer · 2025Review
- Effect of Green Tea (Pathogens (Basel, Switzerland) · 2025Article
- Dencichine attenuates the virulence of Fusobacterium nucleatum by targeting hydrogen sulfide-producing enzyme.International microbiology : the official journal of the Spanish Society for Microbiology · 2025Article
- Quercetin and Silybin Decrease Intracellular Replication ofInternational journal of molecular sciences · 2025Article
- Polyphenolic compounds in combating MDR periodontal pathogens: current research and future directions.Frontiers in pharmacology · 2025Review
- Epigallocatechin-3-gallate therapeutic potential in human diseases: molecular mechanisms and clinical studies.Molecular biomedicine · 2024Review
- Screening inhibitors against the Ef-Tu of Fusobacterium nucleatum: a docking, ADMET and PBPK assessment study.Molecular diversity · 2024Article
- The Relationship Between the Growth ofReports of biochemistry & molecular biology · 2024Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fusobacterium nucleatum plays a key role in creating the pathogenic subgingival biofilm that initiates destructive periodontitis. It is also a common resident of the human gastrointestinal tract and has been associated with inflammatory bowel disease. The aim of the present study was to investigate the effects of green and black tea extracts as well as two of their bioactive components, EGCG and theaflavins, on the growth and virulence properties of F. nucleatum. The tea extracts and components displayed various degrees of antibacterial activity that may involve damage to the bacterial cell membrane and the chelation of iron. They also prevented biofilm formation by F. nucleatum at concentrations that did not interfere with bacterial growth. In addition, the treatment of a pre-formed F. nucleatum biofilm with the green tea extract and EGCG caused a time-dependent decrease in biofilm viability. The green and black tea extracts, EGCG, and theaflavins decreased the adherence of F. nucleatum to oral epithelial cells and matrix proteins. Moreover, these tea components also attenuated F. nucleatum-mediated hemolysis and hydrogen sulfide production, two other virulence factors expressed by this bacterium. In summary, this study showed that tea polyphenols may be of interest for treating F. nucleatum-associated disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.