ArticleMolecular psychiatry2018
Neuroanatomic, epigenetic and genetic differences in monozygotic twins discordant for attention deficit hyperactivity disorder.
Article in Molecular psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.
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Who cites it
36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 68 citations in OpenAlex.
- Epigenome-wide DNA methylation in externalizing behaviours: A review and combined analysis.Neuroscience and biobehavioral reviews · 2023Pooled it
- DNA methylation and brain structure and function across the life course: A systematic review.Neuroscience and biobehavioral reviews · 2020Pooled it
- Classification of familial and non-familial ADHD using auto-encoding network and binary hypothesis testing.Brain research bulletin · 2026Article
- Regional cerebellar structural deficits distinguish psychostimulant-free ADHD youth with and without familial risk for bipolar I disorder: a cross-sectional morphometric analysis.Journal of child psychology and psychiatry, and allied disciplines · 2026Article
- Prenatal stress selectively enhances locomotor hyperactivity in male mice with embryonic loss ofFrontiers in psychiatry · 2026Article
- Cognitive, neuroimaging, and genetic insights on the interthalamic adhesion from a large cohort study of 591 subjects.Scientific reports · 2025Article
- Brain region and cell type-specific DNA methylation profiles in association with ADHD.Scientific reports · 2025Article
- White Matter Microstructural Abnormalities in Children with Familial vs. Non-Familial Attention-Deficit/Hyperactivity Disorder (ADHD).Biomedicines · 2025Article
- Article
- Genome-wide DNA methylation analysis of hippocampal tissue in a murine model of attention deficit-hyperactivity disorder.PloS one · 2025Article
- Cortico-striatal differences in the epigenome in attention-deficit/ hyperactivity disorder.Translational psychiatry · 2024Article
- Epigenome-wide association study identifies neonatal DNA methylation associated with two-year attention problems in children born very preterm.Translational psychiatry · 2024Article
- Advances in the etiology and neuroimaging of children with attention deficit hyperactivity disorder.Frontiers in pediatrics · 2024Review
- DNA methylation is associated with prenatal exposure to sulfur dioxide and childhood attention-deficit hyperactivity disorder symptoms.Scientific reports · 2023Article
- Predicting childhood and adolescent attention-deficit/hyperactivity disorder onset: a nationwide deep learning approach.Molecular psychiatry · 2023Article
- An overview on neurobiology and therapeutics of attention-deficit/hyperactivity disorder.Discover mental health · 2023Review
- Distinct Thalamic and Frontal Neuroanatomical Substrates in Children with Familial vs. Non-Familial Attention-Deficit/Hyperactivity Disorder (ADHD).Brain sciences · 2022Article
- Epigenetics and ADHD: Reflections on Current Knowledge, Research Priorities and Translational Potential.Molecular diagnosis & therapy · 2022Article
- The Role of Epigenetics in the Pathogenesis and Potential Treatment of Attention Deficit Hyperactivity Disorder.Current neuropharmacology · 2022Review
- Epigenetics and ADHD.Current topics in behavioral neurosciences · 2022Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
The study of monozygotic twins discordant for attention deficit hyperactivity disorder can elucidate mechanisms that contribute to the disorder, which affects ~7% of children. First, using in vivo neuroanatomic imaging on 14 pairs of monozygotic twins (mean age 9.7, s.d. 1.9 years), we found that discordance for the disorder is mirrored by differing dimensions of deep brain structures (the striatum and cerebellum), but not the cerebral cortex. Next, using whole-blood DNA from the same twins, we found a significant enrichment of epigenetic differences in genes expressed in these 'discordant' brain structures. Specifically, there is differential methylation of probes lying in the shore and shelf and enhancer regions of striatal and cerebellar genes. Notably, gene sets pertaining to the cerebral cortex (which did not differ in volume between affected and unaffected twins) were not enriched by differentially methylated probes. Genotypic differences between the twin pairs-such as copy number and rare, single-nucleotide variants-did not contribute to phenotypic discordance. Pathway analyses of the genes implicated by the most differentially methylated probes implicated γ-aminobutyric acid (GABA), dopamine and serotonin neurotransmitter systems. The study illustrates how neuroimaging can help guide the search for epigenomic mechanisms in neurodevelopmental disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.