ArticleNature communications2017
Real-time reliable determination of binding kinetics of DNA hybridization using a multi-channel graphene biosensor.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 119 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
119 citing papers in PubMed, 427 citations in OpenAlex.
- Induced Molecular Orientation Transition via Organic-Inorganic Hybrid Networks in Thin-Film Transistor-Based Biosensors.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- A Unique Sandwich Structure Consisting of Graphene and Pyrene Derivatives for Ultraviolet Light Sensor.Sensors (Basel, Switzerland) · 2026Article
- A Novel Electrochemical Sensor Based on r-GO@SiC Nanocomposite Materials for the Highly Sensitive Detection of Metronidazole.Molecules (Basel, Switzerland) · 2026Article
- Recent Advances in Graphene-Based Field-Effect Transistor Biosensors for Disease Biomarker Detection and Clinical Prospects.Biosensors · 2026Review
- Optimizing Surface Functionalization for Aptameric Graphene Nanosensors in Undiluted Physiological Media.Sensors (Basel, Switzerland) · 2026Article
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- Continuous Optical Biosensing of IL-8 Cancer Biomarker Using a Multimodal Platform.Bioengineering (Basel, Switzerland) · 2025Article
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- Plasmonic DNA-Barcoded Virion Nano-Oscillators for Multiplexed Quantification of Small-Molecule Binding Kinetics to Membrane Proteins.Angewandte Chemie (International ed. in English) · 2025Article
- Quantum Simulation Study of Ultrascaled Label-Free DNA Sensors Based on Sub-10 nm Dielectric-Modulated TMD FETs: Sensitivity Enhancement Through Downscaling.Micromachines · 2025Article
- Advanced Materials for Biological Field-Effect Transistors (Bio-FETs) in Precision Healthcare and Biosensing.Advanced healthcare materials · 2025Review
- Generalizable Molecular Switch Designs forAccounts of chemical research · 2025Article
- Light-Triggered Graphene/Black Phosphorus Heterostructure FET Platform for Ultrasensitive Detection of Alzheimer's Disease Biomarkers at the Zeptomole Level.Research (Washington, D.C.) · 2025Article
- Surface-Functionalizing Strategies for Multiplexed Molecular Biosensing: Developments Powered by Advancements in Nanotechnologies.Nanomaterials (Basel, Switzerland) · 2024Review
- A drug-mediated organic electrochemical transistor for robustly reusable biosensors.Nature materials · 2024Article
- Modular Fabrication of Microfluidic Graphene FET for Nucleic Acids Biosensing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Advances in Genotyping Detection of Fragmented Nucleic Acids.Biosensors · 2024Review
- Review
- Graphene-based nanotechnology in the Internet of Things: a mini review.Discover nano · 2024Review
- Organic Electrochemical Transistors for Biomarker Detections.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
59 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Reliable determination of binding kinetics and affinity of DNA hybridization and single-base mismatches plays an essential role in systems biology, personalized and precision medicine. The standard tools are optical-based sensors that are difficult to operate in low cost and to miniaturize for high-throughput measurement. Biosensors based on nanowire field-effect transistors have been developed, but reliable and cost-effective fabrication remains a challenge. Here, we demonstrate that a graphene single-crystal domain patterned into multiple channels can measure time- and concentration-dependent DNA hybridization kinetics and affinity reliably and sensitively, with a detection limit of 10 pM for DNA. It can distinguish single-base mutations quantitatively in real time. An analytical model is developed to estimate probe density, efficiency of hybridization and the maximum sensor response. The results suggest a promising future for cost-effective, high-throughput screening of drug candidates, genetic variations and disease biomarkers by using an integrated, miniaturized, all-electrical multiplexed, graphene-based DNA array.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.