ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2017
Cognitive decline associated with pathological burden in primary age-related tauopathy.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 73 citations in OpenAlex.
- Cardiovascular risk factors and vascular neuropathological findings in primary age-related tauopathy versus Alzheimer's disease.GeroScience · 2026Article
- Diagnostic performance of verbal fluency measures: a cross-sectional study in the stages of cognitive continuum.Alzheimer's research & therapy · 2026Article
- Primary age-related tauopathy.Acta neuropathologica · 2025Review
- Alzheimer mimicry: LATE and PART.Journal of neural transmission (Vienna, Austria : 1996) · 2025Review
- Overview of Proteomic Analysis of Amyloid Plaques and Neurofibrillary Tangles in Alzheimer's Disease.Biomolecules · 2025Review
- Cognitive decline in community-dwelling older persons with primary age-related tauopathy: role of anatomical location of tangles and other co-existing brain pathologies.Acta neuropathologica · 2025Article
- Transcriptional signatures of hippocampal tau pathology in primary age-related tauopathy and Alzheimer's disease.Cell reports · 2025Article
- Lewy body co-pathology in Alzheimer's disease and primary age-related tauopathy contributes to differential neuropathological, cognitive, and brain atrophy patterns.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Distinct biological property of tau in tau-first cognitive proteinopathy: Evidence by longitudinal clinical neuroimaging profiles and compared with late-onset Alzheimer disease.Psychiatry and clinical neurosciences · 2024Article
- Clinical Significance of the Plasma Biomarker Panels in Amyloid-Negative and Tau PET-Positive Amnestic Patients: Comparisons with Alzheimer's Disease and Unimpaired Cognitive Controls.International journal of molecular sciences · 2024Article
- Significance of a positive tau PET scan with a negative amyloid PET scan.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Spatial proteomics of hippocampal subfield-specific pathology in Alzheimer's disease and primary age-related tauopathy.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Loss of TDP-43 splicing repression occurs early in the aging population and is associated with Alzheimer's disease neuropathologic changes and cognitive decline.Acta neuropathologica · 2023Article
- Hippocampal synaptic alterations associated with tau pathology in primary age-related tauopathy.Journal of neuropathology and experimental neurology · 2023Article
- Age-related and amyloid-beta-independent tau deposition and its downstream effects.Brain : a journal of neurology · 2023Article
- Hippocampal Synaptic Alterations Associated with Tau Pathology in Primary Age-Related Tauopathy.medRxiv : the preprint server for health sciences · 2023Article
- Artificial intelligence-derived neurofibrillary tangle burden is associated with antemortem cognitive impairment.Acta neuropathologica communications · 2022Article
- Phosphorylated Tau in Alzheimer's Disease and Other Tauopathies.International journal of molecular sciences · 2022Review
- TDP-43 Pathology Exacerbates Cognitive Decline in Primary Age-Related Tauopathy.Annals of neurology · 2022Article
- Divergent magnetic resonance imaging atrophy patterns in Alzheimer's disease and primary age-related tauopathy.Neurobiology of aging · 2022Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
introductionPrimary age-related tauopathy (PART) is a neuropathological diagnosis characterized by tau neurofibrillary tangles (NFTs) in the absence of amyloid plaque pathology. Although most individuals over 50 years of age have evidence of NFTs, the clinical and cognitive consequences of PART are not known.
methodsWe evaluated 226 neuropathologically confirmed PART cases from the National Alzheimer's Coordinating Center database who participated in a total of 846 longitudinal neuropsychological assessments from the Alzheimer's Disease Center program's Uniform Data Set. Mixed-effects statistical models tested whether cognitive decline was associated with Braak stage NFT burden.
resultsHigher stages of NFT burden in PART, with no evidence or minimal evidence of amyloid pathology, were associated with more rapid decline on tasks involving episodic and semantic memory along with tests of processing speed and attention. DISCUSSION: We conclude that PART has cognitive consequences that should be considered in the context of emerging tau-targeted therapies in age-associated neurodegenerative diseases.
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