Observational studyThe Journal of international medical research2016
Could neutrophil/lymphocyte ratio be an indicator of coronary artery disease, coronary artery ectasia and coronary slow flow?
Observational study in The Journal of international medical research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Unravelling the Link between Inflammatory Biomarkers and Coronary Artery Ectasia Severity: A Systematic Review and Meta-Analysis.Cardiology · 2026Pooled it
- Neutrophil Lymphocyte Ratio and Cardiovascular Disease Risk: A Systematic Review and Meta-Analysis.BioMed research international · 2018Pooled it
- Examination of coronary artery ectasia predictors in acute coronary syndrome.Biomarkers in medicine · 2025Article
- Neutrophil-Percentage-to-Albumin Ratio as a Predictor of Coronary Artery Ectasia: A Comparative Analysis with Inflammatory Biomarkers.Diagnostics (Basel, Switzerland) · 2025Article
- Predictors and clinical outcomes of slow flow phenomenon in diabetic patients with chronic coronary syndrome.BMC cardiovascular disorders · 2024Article
- The Role of Neutrophil to Lymphocyte Ratio and its Common Clinical Outcomes Among Patients with Non-ST Elevation Acute Coronary Syndrome.Journal of the Saudi Heart Association · 2023Article
- Inflammatory Biomarkers in Coronary Artery Ectasia: A Systematic Review and Meta-Analysis.Diagnostics (Basel, Switzerland) · 2022Review
- Association of the lymphocyte-to-monocyte ratio, mean diameter of coronary arteries, and uric acid level with coronary slow flow in isolated coronary artery ectasia.BMC cardiovascular disorders · 2021Article
- Anti-inflammatory effects of rosuvastatin treatment on coronary artery ectasia patients of different age groups.BMC cardiovascular disorders · 2020Article
- Increased plasma lipoprotein-associated phospholipase A2 levels are associated with coronary slow flow.BMC cardiovascular disorders · 2020Article
- Observational
- A new inflammatory marker: elevated eosinophil-tolymphocyte ratio associated with presence and severity of isolated coronary artery ectasia.Cardiovascular journal of AfricaArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective To determine whether neutrophil/lymphocyte ratio (NLR) differed between patients with isolated coronary artery disease (CAD), isolated coronary artery ectasia (CAE), coronary slow flow and normal coronary anatomy. Methods Patients who underwent coronary angiography were consecutively enrolled into one of four groups: CAD, coronary slow flow, CAE and normal coronary anatomy. Results The CAD ( n = 40), coronary slow flow ( n = 40), and CAE ( n = 40) groups had similar NLRs (2.51 ± 0.7, 2.40 ± 0.8, 2.6 ± 0.6, respectively) that were significantly higher than patients with normal coronary anatomy ( n = 40; NLR, 1.73 ± 0.7). Receiver operating characteristics demonstrated that with NLR > 2.12, specificity in predicting isolated CAD was 85% and sensitivity was 75%, with NLR > 2.22 specificity in predicting isolated CAE was 86% and sensitivity was 75%. With NLR > 1.92, specificity in predicting coronary slow flow was 89% and sensitivity was 75%. Multivariate logistic regression analyses identified NLR as an independent predictor of isolated CAE (β = -0.499, 95% CI -0.502, -0.178; P < 0.001), CAD (β = -0.426, 95% CI -1.321, -0.408; P < 0.001), and coronary slow flow (β = -0.430, 95% CI -0.811, -0.240; P = 0.001 Table 2 ). Conclusions NLR was higher in patients with CAD, coronary slow flow and CAE versus normal coronary anatomy. NLR may be an indicator of CAD, CAE and coronary slow flow.
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