Evidence map›Paper›PMID 28322082›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2018

Masato Kobayashi, Teresa Jiang, Sanjay Telu, Sami S Zoghbi, Roger N Gunn, Eugenii A Rabiner, David R Owen, Qi Guo, Victor W Pike, Robert B Innis and 1 more

Open access · bronzeAbstract readComparative Study
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 3 pooled it
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 3 syntheses or guidelines pooled it, 67 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Building a database for brain 18 kDa translocator protein imaged using [Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019
    Trial
  5. Article
  6. rs6971 TSPO polymorphism in Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society · 2026
    Article
  7. Comparing and combining TSPO-PET tracers in tauopathies.European journal of nuclear medicine and molecular imaging · 2026
    Article
  8. Review
  9. Validating the Utility of Supervised Clustering Algorithm for Precise [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Article
  10. Article
  11. Review
  12. [Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024
    Article
  13. PET Imaging to Measure Neuroinflammation In Vivo.Methods in molecular biology (Clifton, N.J.) · 2024
    Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Translation ofNature protocols · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Masato Kobayashi1 Molecular Imaging Branch, National Institute of Mental Health, National Institute of Health, Bethesda, MD, USA.
Teresa Jiang1 Molecular Imaging Branch, National Institute of Mental Health, National Institute of Health, Bethesda, MD, USA.
Sanjay Telu1 Molecular Imaging Branch, National Institute of Mental Health, National Institute of Health, Bethesda, MD, USA.
Sami S Zoghbi1 Molecular Imaging Branch, National Institute of Mental Health, National Institute of Health, Bethesda, MD, USA.
Roger N Gunn2 Imanova Ltd, London, UK.
Eugenii A Rabiner2 Imanova Ltd, London, UK.
David R Owen3 Division of Brain Sciences, Department of Medicine, Imperial College, London, UK.
Qi Guo2 Imanova Ltd, London, UK.
Victor W Pike1 Molecular Imaging Branch, National Institute of Mental Health, National Institute of Health, Bethesda, MD, USA.
Robert B Innis1 Molecular Imaging Branch, National Institute of Mental Health, National Institute of Health, Bethesda, MD, USA.
Masahiro Fujita1 Molecular Imaging Branch, National Institute of Mental Health, National Institute of Health, Bethesda, MD, USA.
National Institute of Mental Health · USImperial College London · GB

Funding

PET Radiopharmaceutical SciencesZIAMH002793 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI PIKE, VICTOR W · 2009 to 2025
$69.8M
Clinical Evaluation of PET RadiotracersZIAMH002852 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI INNIS, ROBERT · 2009 to 2025
$48.6M
Medical Research Council MR/N008219/1NIMH NIH HHS ZIA MH002793NIMH NIH HHS ZIA MH002852
6 · The paper itself

Abstract

Positron emission tomography (PET) radioligands for translocator protein 18 kDa (TSPO) are widely used to measure neuroinflammation, but controversy exists whether second-generation radioligands are superior to the prototypical agent

Indexed as

AcetamidesAdultBrainCarbon RadioisotopesCerebral ArteriesCerebrovascular CirculationFemaleHealthy VolunteersHumansIsoquinolinesMalePolymorphism, GeneticPositron-Emission TomographyProtein BindingPurinesPyrazolesAcetamidesCarbon-11Carbon RadioisotopesIsoquinolinesN-benzyl-N-ethyl-2-(7,8-dihydro-7-methyl-8-oxo-2-phenyl-9H-purin-9-yl)acetamideN,N-diethyl-2-(2-(4-methoxyphenyl)-5,7-dimethyl-pyrazolo(1,5-a)pyrimidin-3-yl)-acetamidePK 11195PurinesPyrazolesPyrimidinesRadiopharmaceuticalsReceptors, GABATSPO protein, human18 kDa (TSPO)metabolite-corrected arterial inputpositron emission tomographyrs6971 polymorphismXBD173

Identifiers

PMID28322082
PMCPMC5851139
OpenAlexW2598860360

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.