Observational studyJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2018
Enteral nutrition increases interstitial brain glucose levels in poor-grade subarachnoid hemorrhage patients.
Observational study in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 23 citations in OpenAlex.
- Determinants of Brain Tissue Normoxia in Patients with Large Spontaneous Intracerebral Hemorrhage.Neurocritical care · 2026Article
- Glucose and Lactate Concentrations in Plasma, Cerebrospinal Fluid, and Brain Parenchyma Following Aneurysmal Subarachnoid Hemorrhage: A Cross-compartmental Correlation Study.Neurocritical care · 2026Article
- Consensus statement from the 2025 Delphi panel on cerebral microdialysis in critical care.Critical care (London, England) · 2026Review
- Relationship Between Systemic and Cerebral Microdialysate Glucose in Patients With Severe Acute Brain Injury-A Retrospective Study.Acta anaesthesiologica Scandinavica · 2025Observational
- Liberalization of the Systemic Glucose Management is Associated with a Reduced Frequency of Neuroglucopenia in Subarachnoid Hemorrhage Patients: An Observational Cohort Study.Neurocritical care · 2025Observational
- Optimization of Nutrition after Brain Injury: Mechanistic and Therapeutic Considerations.Biomedicines · 2023Review
- Early Enteral Nutrition with High-Protein Whey Peptide Digestive Nutrients May Improve Prognosis in Subarachnoid Hemorrhage Patients.Medicina (Kaunas, Lithuania) · 2022Article
- A Study of the Relationship between Blood Glucose and Serum Insulin in Acute Cerebrovascular Disease.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Cerebral multimodality monitoring in adult neurocritical care patients with acute brain injury: A narrative review.Frontiers in physiology · 2022Review
- Nutrition in the Neurocritical Care Unit: a New Frontier.Current treatment options in neurology · 2021Review
- Update: Microdialysis for Monitoring Cerebral Metabolic Dysfunction after Subarachnoid Hemorrhage.Journal of clinical medicine · 2020Review
- Nutrition Therapy, Glucose Control, and Brain Metabolism in Traumatic Brain Injury: A Multimodal Monitoring Approach.Frontiers in neuroscience · 2020Review
- Understanding and monitoring brain injury: the role of cerebral microdialysis.Intensive care medicine · 2018Article
- Cerebral Microdialysis Monitoring to Improve Individualized Neurointensive Care Therapy: An Update of Recent Clinical Data.Frontiers in neurology · 2017Review
- Clinical Use of Cerebral Microdialysis in Patients with Aneurysmal Subarachnoid Hemorrhage-State of the Art.Frontiers in neurology · 2017Review
- Clinical observation of individualized nutritional formula on inflammation index, immune status and gastrointestinal tolerance in patients with severe head injury.Pakistan journal of medical sciencesArticle
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Low brain tissue glucose levels after acute brain injury are associated with poor outcome. Whether enteral nutrition (EN) reliably increases cerebral glucose levels remains unclear. In this retrospective analysis of prospectively collected observational data, we investigate the effect of EN on brain metabolism in 17 poor-grade subarachnoid hemorrhage (SAH) patients undergoing cerebral microdialysis (CMD) monitoring. CMD-values were obtained hourly. A nutritional intervention was defined as the clinical routine administration of EN without supplemental parenteral nutrition. Sixty-three interventions were analyzed. The mean amount of EN per intervention was 472.4 ± 10.7 kcal. CMD-glucose levels significantly increased from 1.59 ± 0.13 mmol/l at baseline to a maximum of 2.03 ± 0.2 mmol/l after 5 h (p < 0.001), independently of insulin-treatment, baseline serum glucose, baseline brain metabolic distress (CMD-lactate-to-pyruvate-ratio (LPR) > 40) and the microdialysis probe location. The increase in CMD-glucose was directly dependent on the magnitude of increase of serum glucose levels (p = 0.007). No change in CMD-lactate, CMD-pyruvate, CMD-LPR, or CMD-glutamate (p > 0.4) was observed. Routine EN also increased CMD-glucose even if baseline concentrations were critically low ( < 0.7 mmol/l, neuroglucopenia; p < 0.001). These results may have treatment implications regarding glucose management of poor-grade aneurysmal SAH patients.
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