ArticleThe Plant journal : for cell and molecular biology2017
Disruptions in valine degradation affect seed development and germination in Arabidopsis.
Article in The Plant journal : for cell and molecular biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 78 citations in OpenAlex.
- Article
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- 1-Aminocyclopropane-1-carboxylic acid induces resource reallocation inFrontiers in plant science · 2025Article
- Synthesis of β-Alanine From Isoleucine and Propionate Catabolism via Aminotransferases.Plant direct · 2024Article
- Dissecting the temporal genetic networks programming soybean embryo development from embryonic morphogenesis to post-germination.Plant cell reports · 2024Article
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- Redox dynamics in seeds ofFrontiers in plant science · 2024Article
- Phosphate Transporter OsPT4, Ubiquitinated by E3 Ligase OsAIRP2, Plays a Crucial Role in Phosphorus and Nitrogen Translocation and Consumption in Germinating Seed.Rice (New York, N.Y.) · 2023Article
- GWAS Combined with WGCNA of Transcriptome and Metabolome to Excavate Key Candidate Genes for Rice Anaerobic Germination.Rice (New York, N.Y.) · 2023Article
- Zinc Oxide Nanoparticles Affect Early Seedlings' Growth and Polar Metabolite Profiles of Pea (International journal of molecular sciences · 2023Article
- Comparative Metabolomics Profiling Reveals Key Metabolites and Associated Pathways Regulating Tuber Dormancy in White Yam (Metabolites · 2023Article
- Genome-wide association study reveals that GhTRL1 and GhPIN8 affect cotton root development.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2022Article
- Overview of Allelopathic Potential ofMolecules (Basel, Switzerland) · 2022Review
- Genome-wide association study reveals that the cupin domain protein OsCDP3.10 regulates seed vigour in rice.Plant biotechnology journal · 2022Article
- Genome-wide association of the metabolic shifts underpinning dark-induced senescence in Arabidopsis.The Plant cell · 2022Article
- Effect of two postharvest technologies on the micronutrient profile of cashew kernels from Mozambique.Food science & nutrition · 2022Article
- Comparative Metabolomics Reveals Two Metabolic Modules Affecting Seed Germination in Rice (Metabolites · 2021Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
We have functionally characterized the role of two putative mitochondrial enzymes in valine degradation using insertional mutants. Prior to this study, the relationship between branched-chain amino acid degradation (named for leucine, valine and isoleucine) and seed development was limited to leucine catabolism. Using a reverse genetics approach, we show that disruptions in the mitochondrial valine degradation pathway affect seed development and germination in Arabidopsis thaliana. A null mutant of 3-hydroxyisobutyryl-CoA hydrolase (CHY4, At4g31810) resulted in an embryo lethal phenotype, while a null mutant of methylmalonate semialdehyde dehydrogenase (MMSD, At2g14170) resulted in seeds with wrinkled coats, decreased storage reserves, elevated valine and leucine, and reduced germination rates. These data highlight the unique contributions CHY4 and MMSD make to the overall growth and viability of plants. It also increases our knowledge of the role branched-chain amino acid catabolism plays in seed development and amino acid homeostasis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.