Evidence map›Paper›PMID 28321830›Full record

ReviewThe AAPS journal2017

Current Trends in Ligand Binding Real-Time Measurement Technologies.

Stephanie Fraser, Judy Y Shih, Mark Ware, Edward O'Connor, Mark J Cameron, Martin Schwickart, Xuemei Zhao, Karin Regnstrom

Abstract readReview
PubMed Publisher
In one paragraph

Review in The AAPS journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Stephanie FraserPfizer, Eastern Point Rd, Groton, Connecticut, 06340, USA. Stephanie.Fraser@pfizer.com.ORCID 0000-0002-1946-9402
Judy Y ShihAmgen Inc., One Amgen Center Drive, Thousand Oaks, California, 91320, USA.
Mark WareJanssen Research & Development, LLC, 1400 McKean Road, Spring House, Pennsylvania, 19477, USA.
Edward O'ConnorAegisBioconsult, 78 Marbern Dr., Suffield, Connecticut, 06078, USA.
Mark J CameronLumigen, 22900 8 Mile Road, Southfield, Michigan, 48033, USA.
Martin SchwickartMedImmune, 319 N. Bernardo Ave, Mountain View, California, 94043, USA.
Xuemei ZhaoMerck Research Laboratories, Rahway, New Jersey, 07065, USA.
Karin RegnstromBoehringer Ingelheim, 6701 Kaiser Drive, Fremont, California, 94555, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Numerous advances in ligand binding assay (LBA) real-time measurement technologies have been made within the last several years, ranging from the development of novel platforms to drive technology expansion to the adaptation of existing platforms to optimize performance and throughput. In this review, we have chosen to focus on technologies that provide increased value to two distinct segments of the LBA community. First, experimentally, by measuring real-time binding events, these technologies provide data that can be used to interrogate receptor/ligand binding interactions. While overall the platforms are not new, they have made significant advances in throughput, multiplexing, and/or sensitivity. Second, clinically, these point-of-care (POC) technologies provide instantaneous information which facilitates rapid treatment decisions.

Indexed as

BiochemistryLab-On-A-Chip DevicesQuartz Crystal Microbalance TechniquesSurface Plasmon Resonanceemergent technology reviewlateral flow immunoassayligand binding assayreal-time measurementsurface plasmon resonance

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.