Evidence map›Paper›PMID 28321826›Full record

Trial reportProbiotics and antimicrobial proteins2017

The Role of Probiotics in the Treatment of Dysentery: a Randomized Double-Blind Clinical Trial.

Alireza Sharif, Hamed Haddad Kashani, Elahe Nasri, Zahra Soleimani, Mohammad Reza Sharif

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Probiotics and antimicrobial proteins, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 4 pooled it
5.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 4 syntheses or guidelines pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Probiotics for treating acute infectious diarrhoea.The Cochrane database of systematic reviews · 2020
    Pooled it
  4. Antiamoebic drugs for treating amoebic colitis.The Cochrane database of systematic reviews · 2019
    Pooled it
  5. Trial
  6. Trial
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  8. Review
  9. Article
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  17. A Novel Chimeric Endolysin with Antibacterial Activity against Methicillin-ResistantFrontiers in cellular and infection microbiology · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Alireza SharifInfectious Diseases Research Center, Kashan University of Medical Sciences, Kashan, Iran.
Hamed Haddad KashaniAnatomical Sciences Research Center, Kashan University of Medical Sciences, Kashan, Iran.
Elahe NasriInfectious Diseases Research Center, Kashan University of Medical Sciences, Kashan, Iran.
Zahra SoleimaniInfectious Diseases Research Center, Kashan University of Medical Sciences, Kashan, Iran.
Mohammad Reza SharifInfectious Diseases Research Center, Kashan University of Medical Sciences, Kashan, Iran. mrsharifmd@yahoo.com.
Kashan University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diarrhea is considered as an important cause of morbidity and mortality, even though one of the main reasons of death following diarrhea is initiated by dysentery. In recent years, the consumption of probiotics has been proposed for the treatment of infectious diarrhea. Despite most of the studies on probiotics have focused on acute watery diarrhea, few studies in the field of dysentery have found beneficial effects of probiotics. This study is a randomized double-blind clinical trial. The patients were randomly placed into control and case groups. In the intervention group, the patients received probiotics in the form of Kidilact® sachet, which contained high amounts of 7-strain friendly bacteria strains of Lactobacillus casei, Lactobacillus acidophilus, Lactobacillus rhamnosus, Lactobacillus bulgaricus, Bifidobacterium infantis, Bifidobacterium breve, and Streptococcus thermophiles. On the other hand, the patients in the control group received placebo sachets on a daily basis for 5 days. It is notable that the treatment protocol of acute dysentery was done on both groups. The results of this study showed significant differences in the duration of blood in diarrhea between probiotic consumers (2.62 days) and the control group (3.16 days) (P value = 0.05). Additionally, significant differences in the average length of hospitalization in probiotic consumers (3.16 days) and control (3.66 days), (P value = 0.02) could be claimed that the consumption of probiotics is effective in reducing the duration of dysentery and diarrhea. The results of this study suggest that the use of probiotics can be effective in reducing the duration of blood in diarrhea. This study was also recorded in the Iran center of clinical trials registration database (IRCT2014060617985N1).

Indexed as

AdultBifidobacterium breveBifidobacterium longum subspecies infantisDiarrheaDouble-Blind MethodDysenteryFemaleHospitalizationHumansIranLacticaseibacillus caseiLacticaseibacillus rhamnosusLactobacillus acidophilusLactobacillus delbrueckiiMaleProbioticsBacteriaBifidobacteriumDiarrheaDysenteryFeverLactobacillusPatientProbioticsStreptococcus

Identifiers

PMID28321826
OpenAlexW2602173773

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.