Evidence map›Paper›PMID 28321817›Full record

ReviewAdvances in experimental medicine and biology2017

Adverse Events in Cancer Immunotherapy.

Noha Abdel-Wahab, Anas Alshawa, Maria E Suarez-Almazor

Abstract readReview
PubMed Publisher
In one paragraph

Review in Advances in experimental medicine and biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 3 pooled it
46.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 3 syntheses or guidelines pooled it, 59 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 2 countries.

Noha Abdel-WahabSection of Rheumatology and Clinical Immunology, Department of General Internal Medicine, University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, 77030, USA.
Anas AlshawaDepartment of Investigational Cancer Therapeutics, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Maria E Suarez-AlmazorSection of Rheumatology and Clinical Immunology, Department of General Internal Medicine, University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, 77030, USA. msalmazor@mdanderson.org.
The University of Texas MD Anderson Cancer Center · US

Funding

Outcomes Research in Rheumatic Diseases: A Mentoring ProgramK24AR053593 · NIAMS · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI SUAREZ-ALMAZOR, MARIA E · 2006 to 2015
$2.0M
NIAMS NIH HHS K24 AR053593
6 · The paper itself

Abstract

Cancer immunotherapy has resulted in durable responses in patients with metastatic disease, unseen with traditional chemotherapy. Several therapies have been approved by the Food and Drug Administration for the treatment of various cancers, including: immune checkpoint inhibitors, cytokines - interleukin 2 (IL-2) and interferon alpha (IFN), and the cancer vaccine sipuleucel-T. These therapies upregulate the immune system to enhance antitumor responses. As a consequence, they can cause inflammatory and immune-related adverse events that can affect one or more organs, can be serious, and on occasion lifethreatening. The management of these adverse events is complex, and requires a multidisciplinary approach involving not only oncologists, but also other internal medicine specialists, to ensure prompt diagnosis and optimal management of these complications.

Indexed as

AnimalsAntineoplastic AgentsCancer VaccinesHumansImmunotherapyMolecular Targeted TherapyNeoplasmsPatient SafetyRisk AssessmentRisk FactorsTreatment OutcomeAntineoplastic AgentsCancer VaccinesCancer immunotherapyCancer vaccineCytokinesImmune checkpoint inhibitorsImmune-related adverse events

Identifiers

PMID28321817
OpenAlexW2598424499

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.