ReviewHead and neck pathology2017
Paragangliomas of the Head and Neck: An Overview from Diagnosis to Genetics.
Review in Head and neck pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
72 citing papers in PubMed, 1 synthesis or guideline pooled it, 164 citations in OpenAlex.
- Japan Endocrine Society Clinical Practice Guideline for the Diagnosis and Management of Pheochromocytoma and Paraganglioma 2025.Endocrine journal · 2026Guideline
- Treatment Outcomes of Radiation Therapy of Paragangliomas of the Head and Neck at a Single Institution.International journal of particle therapy · 2026Article
- Metastatic Carotid Body Paraganglioma Following Three Decades of Indolent Growth: A Case Report.Cureus · 2026Article
- The New Tumor Predisposition Syndromes with Neuro-Oncological Relevance-A Comprehensive Review for Neuroradiologists.Clinical neuroradiology · 2026Review
- Submucosal laryngeal lesions: A puzzling diagnostic conundrum.European journal of radiology open · 2026Review
- Mapping the neglected topic in head and neck paraganglioma research: a PRISMA scoping review on quality of life.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026Article
- Surgical resection versus stereotactic radiosurgery for succinate dehydrogenase-related hereditary head and neck paragangliomas.Journal of neuro-oncology · 2026Article
- From Syncope to Stroke: Vascular Complications of Skull Base Paraganglioma.European journal of case reports in internal medicine · 2026Article
- Case Report: Carotid body paraganglioma in a 20-year-old woman: multimodal imaging, vessel-preserving surgical excision, and long-term clinical follow-up.Frontiers in surgery · 2026Article
- Succinate Dehydrogenase Pathogenic Variants Among Older Adults With Head and Neck Paragangliomas.Laryngoscope investigative otolaryngology · 2025Article
- Current Understanding of Carotid Body Paraganglioma Management.Vascular specialist international · 2025Review
- Pros and cons of surgical versus conservative management for head and neck paraganglioma: a real-world data analysis.Endocrine · 2025Article
- Pheochromocytomas and Paragangliomas-Current Management.Cancers · 2025Review
- Unmasking Villaret's syndrome: a diagnostic challenge of glomus jugulare mimicking mastoiditis.Annals of medicine and surgery (2012) · 2025Article
- Optimal Screening for Hereditary Head and Neck Paraganglioma in Asymptomatic SDHx Variant Carriers in the Netherlands.Journal of neurological surgery. Part B, Skull base · 2025Article
- Identification of a pathogenic SDHD mutation in a Chinese family with hereditary head and neck paraganglioma: implications for genetic counseling and management.World journal of surgical oncology · 2025Article
- Management of bilateral head and neck paragangliomas at a single-institution across four decades.Head & neck · 2025Article
- Microsurgical resection of a giant exclusively dopamine- secreting jugular foramen paraganglioma: A case report.Surgical neurology international · 2025Article
- Laryngeal Paraganglioma with Neck Metastasis.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2024Article
- [Advance in HIF expression and immune microenvironment in pseudohypoxic HNPGL].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2024Review
12 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Paragangliomas (PGL) develop from the parasympathetic system in the head and neck (HN) and arise primarily in four distinct areas: Carotid body, vagal, middle ear, and larynx. Globally, the diagnosis and morphologic features are the same regardless of anatomic site, however the incidence, frequency of genetic alterations/syndromes and differential diagnosis vary. It is now recognized that nearly 40% of all HN PGLs are hereditary, including a significant subset without a known family history. Now pathologists are central to the evaluation for diagnosis and further management of patients with HNPGLs. Specifically, SDHB immunohistochemical evaluation is an excellent screening tool to detect tumors with alterations in the SDH family of genes that represent the majority of hereditary cases in HNPGL. Similarly, SDHB immunohistochemical analysis allows for screening of PGL syndrome associated tumors (gastrointestinal stromal tumor (GIST), renal cell carcinoma (RCC), and pituitary adenomas) that have now been linked by their overlapping gene alterations. Awareness of the spectrum of these syndromes, and their associated tumors, positions the pathologist to augment patient care and surveillance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.