ArticleCancer causes & control : CCC2017
Age at diagnosis, obesity, smoking, and molecular subtypes in muscle-invasive bladder cancer.
Article in Cancer causes & control : CCC, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 22 citations in OpenAlex.
- Clinicopathological study and molecular subtyping of muscle-invasive bladder cancer (MIBC) using dual immunohistochemical (IHC) markers.Diagnostic pathology · 2025Article
- Latent heterogeneity of muscle-invasive bladder cancer in patient characteristics and survival: A population-based nation-wide study in the Bladder Cancer Data Base Sweden (BladderBaSe).Cancer medicine · 2023Article
- Characterization of the tumor-infiltrating immune repertoire in muscle invasive bladder cancer.Frontiers in immunology · 2023Article
- A Single Tertiary Center Experience in a South Asian Population: Does Tobacco Use Influence Bladder Cancer?Cureus · 2021Article
- Identification of a Novel Inflamed Tumor Microenvironment Signature as a Predictive Biomarker of Bacillus Calmette-Guérin Immunotherapy in Non-Muscle-Invasive Bladder Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2021Article
- Morbidity, mortality, and quality assessment following open radical cystectomy in elderly patients with bladder cancer.Aging clinical and experimental research · 2021Article
- Risk stratification by means of biological age-related factors better predicts cancer-specific survival than chronological age in patients with upper tract urothelial carcinoma: a multi-institutional database study.Therapeutic advances in urology · 2018Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundHeterogeneity of muscle-invasive bladder cancer (MIBC) has been characterized using whole-genome mRNA expression data, showing distinct molecular and clinicopathological characteristics by subtypes. However, associations between risk factors and molecular subtypes have not been reported.
methodsFour previously published schemes were used to categorize molecular subtypes in 372 MIBC patients from the Cancer Genome Atlas (TCGA). Data on gene expression (RNA-seq), demographic, and clinicopathological characteristics were retrieved through TCGA data portal. Polytomous logistic regression was used to estimate the associations of subtypes by different schemes with age at diagnosis, obesity, and smoking.
resultsWhile some quantitative variation was evident, distinct molecular subtype schemes showed considerable consistency in the association with the risk factors. Generally, compared to patients with luminal-like tumors, patients with basal-like subtypes were more likely to be older (OR
conclusionsDifferent molecular subtypes of MIBC may have distinct risk profiles. Large population-based studies with detailed information on bladder cancer risk factors are needed to further define etiologic heterogeneity for bladder cancer.
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