ArticleBrain imaging and behavior2018
Evidence for cognitive resource imbalance in adolescents with narcolepsy.
Article in Brain imaging and behavior, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- GABA, Glutamate and Neural Activity: A Systematic Review With Meta-Analysis of MultimodalFrontiers in psychiatry · 2021Pooled it
- Dynamic Brain State Alterations in Narcolepsy: A Hidden Markov Model Approach to Thalamocortical Instability and Symptom-Specific Neural Correlates.Brain and behavior · 2026Article
- Attention and inhibition deficits in narcolepsy type 1: behavioral and electrophysiological markers.Translational psychiatry · 2025Article
- Patient experiences of narcolepsy and idiopathic hypersomnia in the Nordics: a patient journey map.Journal of sleep research · 2025Article
- International Swiss Primary Hypersomnolence and Narcolepsy Cohort Study (iSPHYNCS): the impact of psychiatric comorbidities on daily life in central disorders of hypersomnolence-a vicious circle.Journal of sleep research · 2025Article
- Healthcare Burden and Productivity Loss Due to Narcolepsy in Sweden.Clocks & sleep · 2025Article
- Compensatory enhancement of orexinergic system functionality induced by amyloid-β protein: a neuroprotective response in Alzheimer's disease.Frontiers in physiology · 2025Article
- Behavioral and Electrophysiological Markers of Attention Fluctuations in Children with Hypersomnolence.Journal of clinical medicine · 2024Article
- White matter integrity in narcolepsy: the structural blueprint for functional complaints?Sleep · 2024Article
- Characterization of the Increase in Narcolepsy following the 2009 H1N1 Pandemic in Sweden.Journal of clinical medicine · 2024Article
- The nature and magnitude of cognitive impairment in narcolepsy type 1, narcolepsy type 2, and idiopathic hypersomnia: a meta-analysis.Sleep advances : a journal of the Sleep Research Society · 2024Article
- Sleep and Psychosocial Characteristics of Children with Narcolepsy According to Their Intellectual Profile: A Case-Control Study.Journal of clinical medicine · 2022Article
- Increased very low frequency pulsations and decreased cardiorespiratory pulsations suggest altered brain clearance in narcolepsy.Communications medicine · 2022Article
- Neuropsychiatric Correlates of Narcolepsy.Current psychiatry reports · 2020Review
- Lag Analysis of Fast fMRI Reveals Delayed Information Flow Between the Default Mode and Other Networks in Narcolepsy.Cerebral cortex communications · 2020Article
- Structural anomaly in the reticular formation in narcolepsy type 1, suggesting lower levels of neuromelanin.NeuroImage. Clinical · 2019Article
- Unexpected Fat Distribution in Adolescents With Narcolepsy.Frontiers in endocrinology · 2018Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
The study investigated brain activity changes during performance of a verbal working memory task in a population of adolescents with narcolepsy. Seventeen narcolepsy patients and twenty healthy controls performed a verbal working memory task during simultaneous fMRI and EEG acquisition. All subjects also underwent MRS to measure GABA and Glutamate concentrations in the medial prefrontal cortex. Activation levels in the default mode network and left middle frontal gyrus were examined to investigate whether narcolepsy is characterized by an imbalance in cognitive resources. Significantly increased deactivation within the default mode network during task performance was observed for the narcolepsy patients for both the encoding and recognition phases of the task. No evidence for task performance deficits or reduced activation within the left middle frontal gyrus was noted for the narcolepsy patients. Correlation analyses between the spectroscopy and fMRI data indicated that deactivation of the anterior aspect of the default mode in narcolepsy patients correlated more with increased concentrations of Glutamate and decreased concentrations of GABA. In contrast, deactivation in the default mode was correlated with increased concentrations of GABA and decreased concentrations of Glutamate in controls. The results suggested that narcolepsy is not characterized by a deficit in working memory but rather an imbalance of cognitive resources in favor of monitoring and maintaining attention over actual task performance. This points towards dysregulation within the sustained attention system being the origin behind self-reported cognitive difficulties in narcolepsy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.