ArticleThe EMBO journal1987
Homologous recombination in the Dictyostelium alpha-actinin gene leads to an altered mRNA and lack of the protein.
Article in The EMBO journal, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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Who cites it
56 citing papers in PubMed, 166 citations in OpenAlex.
- Unlocking CRISPR-Cas9 editing for widely diverse Dictyostelid species.Molecular systems biology · 2026Article
- TheFrontiers in cell and developmental biology · 2022Article
- Article
- Genetic Engineering of Dictyostelium discoideum Cells Based on Selection and Growth on Bacteria.Journal of visualized experiments : JoVE · 2019Article
- Review
- The Dictyostelium discoideum homologue of Twinkle, Twm1, is a mitochondrial DNA helicase, an active primase and promotes mitochondrial DNA replication.BMC molecular biology · 2018Article
- Article
- The Parkinson's disease-associated protein DJ-1 plays a positive nonmitochondrial role in endocytosis inDisease models & mechanisms · 2017Article
- A Simple Retroelement Based Knock-Down System in Dictyostelium: Further Insights into RNA Interference Mechanisms.PloS one · 2015Article
- Identification of Pentatricopeptide Repeat Proteins in the Model Organism Dictyostelium discoideum.International journal of genomics · 2013Article
- Linking Ras to myosin function: RasGEF Q, a Dictyostelium exchange factor for RasB, affects myosin II functions.The Journal of cell biology · 2008Article
- Filamin repeat segments required for photosensory signalling in Dictyostelium discoideum.BMC cell biology · 2007Article
- GrlJ, a Dictyostelium GABAB-like receptor with roles in post-aggregation development.BMC developmental biology · 2007Article
- Aberrant stalk development and breakdown of tip dominance in Dictyostelium cell lines with RNAi-silenced expression of calcineurin B.BMC developmental biology · 2006Article
- Differential effects of heterochromatin protein 1 isoforms on mitotic chromosome distribution and growth in Dictyostelium discoideum.Eukaryotic cell · 2006Article
- HelF, a putative RNA helicase acts as a nuclear suppressor of RNAi but not antisense mediated gene silencing.Nucleic acids research · 2006Article
- Peptide signaling during terminal differentiation of Dictyostelium.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Revamp a model-status and prospects of the Dictyostelium genome project.Current genetics · 2003Review
- Functions of LIM proteins in cell polarity and chemotactic motility.The EMBO journal · 2002Article
- RNAi in Dictyostelium: the role of RNA-directed RNA polymerases and double-stranded RNase.Molecular biology of the cell · 2002Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mutation of the alpha-actinin gene in Dictyostelium has been achieved by transforming cells with the Dictyostelium transformation vector pDNeoII containing a 1.2 kb fragment of the alpha-actinin gene. Transformants deficient in alpha-actinin, an actin-binding protein, produced an altered mRNA that lacked the 3' portion of the coding region. The defect in alpha-actinin production was not due to integration of the vector within the gene, but was apparently caused by errors produced during homologous recombination between the introduced alpha-actinin sequence and its complementary sequence in the coding region of the endogenous gene.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.