Evidence map›Paper›PMID 28321497›Full record

Trial reportClinical research in cardiology : official journal of the German Cardiac Society2017

Intra-procedural determination of viability by myocardial deformation imaging: a randomized prospective study in the cardiac catheter laboratory.

Alexander Schuh, Vadim Karayusuf, Ertunc Altiok, Sandra Hamada, Jörg Schröder, Andras Keszei, Malte Kelm, Matias de la Fuente, Michael Frick, Klaus Radermacher and 2 more

Erratum issuedAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Clinical research in cardiology : official journal of the German Cardiac Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Differential effects of inhibition of interleukin 1 and 6 on myocardial, coronary and vascular function.Clinical research in cardiology : official journal of the German Cardiac Society · 2019
    Trial
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Alexander SchuhDepartment of Cardiology, RWTH Aachen University, Aachen, Germany.
Vadim KarayusufDepartment of Cardiology, RWTH Aachen University, Aachen, Germany.
Ertunc AltiokDepartment of Cardiology, RWTH Aachen University, Aachen, Germany.
Sandra HamadaDepartment of Cardiology, RWTH Aachen University, Aachen, Germany.
Jörg SchröderDepartment of Cardiology, RWTH Aachen University, Aachen, Germany.
Andras KeszeiDepartment of Medical Statistics, RWTH Aachen University, Aachen, Germany.
Malte KelmDepartment of Cardiology, University Hospital Düsseldorf, Düsseldorf, Germany.
Matias de la FuenteMedical Engineering, Helmholtz Institute for Biomedical Engineering, Aachen, Germany.
Michael FrickDepartment of Cardiology, RWTH Aachen University, Aachen, Germany.
Klaus RadermacherMedical Engineering, Helmholtz Institute for Biomedical Engineering, Aachen, Germany.
Nikolaus MarxDepartment of Cardiology, RWTH Aachen University, Aachen, Germany.
Michael BeckerDepartment of Cardiology, RWTH Aachen University, Aachen, Germany. mibecker@ukaachen.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe benefit of revascularization for functional recovery depends on the presence of viable myocardial tissue.

objectiveMyocardial deformation imaging allows determination of myocardial viability.

methodsIn a first approach, we assessed the optimal cutoff value to determine preserved viability by layer-specific echocardiographic myocardial deformation imaging at rest and low-dose dobutamine (DSE) echocardiography: regional endocardial circumferential strain (eCS) <-19% at rest was as accurate as eCS at DSE. In a main study, 123 patients (66% men, age 59 ± 6 years) with relevant coronary stenoses and corresponding severe regional myocardial dysfunction were included and randomized in 2 groups after coronary angiography: group A: intra-procedural myocardial deformation imaging in the cardiac catheter laboratory (CLab), determination of myocardial viability by regional eCS <-19%, in case of positive viability immediate coronary intervention in the same session. Group B: two-step determination of myocardial viability by cardiovascular magnetic resonance (CMR), in case of positive viability coronary intervention. After 18 months follow-up an analysis of the endpoints regarding cardiovascular events, left ventricular (LV) function, and comparison of cost was performed.

resultsGroup A (N = 61) and group B (N = 62) showed no differences concerning localization of the coronary stenosis, comorbidities, or medical therapy. Cardiovascular events at 18-month follow-up were as follows: group A 13% (N = 10) vs. group B 14% (N = 9, p = 0.288); improvement of LV function: group A: +7 ± 2% vs. group B: +7 ± 3%, p = 0.963; costs: group A: 3096 Dollar vs. group B: 6043 Dollar, p < 0.001.

conclusionIntra-procedural determination of myocardial viability by myocardial deformation imaging in the CLab is feasible, safe, and cost effective and may become an emerging alternative to the current practice of two-stage viability diagnostics.

Indexed as

Cardiac CatheterizationCoronary AngiographyEchocardiography, StressFemaleHumansIntraoperative PeriodMagnetic Resonance Imaging, CineMaleMiddle AgedMyocardial InfarctionMyocardial RevascularizationPilot ProjectsProspective StudiesReproducibility of ResultsVentricular Function, LeftCoronary interventionIntra-proceduralMyocardial deformation imagingMyocardial viability

Identifiers

PMID28321497

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.