ArticleThe EMBO journal1987
Alternative internal splicing in c-myb RNAs occurs commonly in normal and tumor cells.
Article in The EMBO journal, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 31 citations in OpenAlex.
- MicroRNA-195-5p Targets MYB to Regulate Proliferation and Malignant Metastasis in Triple-Negative Breast Cancer via PI3K/AKT/mTOR Signaling.The breast journal · 2025Article
- Single molecule analysis of c-myb alternative splicing reveals novel classifiers for precursor B-ALL.PloS one · 2011Article
- Myb proteins: angels and demons in normal and transformed cells.Frontiers in bioscience (Landmark edition) · 2011Review
- Genome annotation of a 1.5 Mb region of human chromosome 6q23 encompassing a quantitative trait locus for fetal hemoglobin expression in adults.BMC genomics · 2004Article
- A new retroelement constituted by a natural alternatively spliced RNA of murine replication-competent retroviruses.The EMBO journal · 2003Article
- Molecular mechanisms associated with the regulation of apoptosis by the two alternatively spliced products of c-Myb.Molecular and cellular biology · 2003Article
- Article
- Review
- Overexpression of an alternatively spliced form of c-Myb results in increases in transactivation and transforms avian myelomonoblasts.Journal of virology · 1998Article
- Regulation of the biosynthesis of subgroup C adenovirus protein IVa2.Journal of virology · 1991Article
- Alternative splicing of RNAs transcribed from the human c-myb gene.Molecular and cellular biology · 1990Article
- Structure and biological activity of the transcriptional initiation sequences of the murine c-myb oncogene.Nucleic acids research · 1989Article
- A second c-myb protein is translated from an alternatively spliced mRNA expressed from normal and 5'-disrupted myb loci.Molecular and cellular biology · 1989Article
- Developmental and environmental regulation of a phenylalanine ammonia-lyase-beta-glucuronidase gene fusion in transgenic tobacco plants.Proceedings of the National Academy of Sciences of the United States of America · 1989Article
- Hematopoietic lineage-specific heterogeneity in the 5'-terminal region of the chicken proto-myb transcript.Molecular and cellular biology · 1989Article
- RAV-1 insertional mutagenesis: disruption of the c-myb locus and development of avian B-cell lymphomas.Journal of virology · 1989Article
- Provirus tagging as an instrument to identify oncogenes and to establish synergism between oncogenes.Archives of virology · 1988Review
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1 author at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Activation of the c-myb gene by viral transduction or proviral insertional mutagenesis that is likely to result in the production of structurally altered myb proteins has been shown to be predominantly associated with myelomonocytic tumors. An alternative splicing event in which a portion of the intron bounded by the vE6 and vE7 exons with v-myb homology is included as an additional 363-nucleotide coding exon has recently been identified in a mouse tumor that carries a provirus-activated myb gene. This alternative splicing was hypothesized to be a tumor-specific aberrant form of 3'-myb RNA processing as a consequence of the disruption of upstream 5'-sequences by proviral insertion. However, RNA blot analyses and RNase mapping studies presented here show that a significant portion (approximately 10%) of all myb transcripts examined, whether in normal or in clonal tumor cells, contains the additional exon. Hence the alternative splicing is a hitherto unrecognized common normal event that potentially increases the diversity of the myb proteins expressed in normal tissues including thymus and spleen, as well as in tumor cells with either normal or 5'-rearranged myb alleles. The lack of change in the ratio of the two spliced products expressed from either the normal or the 5'-rearranged myb further indicates that the insertion of the unique 121 amino acids in the larger myb transcripts is not a consequence of tumor-specific activation of the mouse myb oncogene.
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