ArticleDiabetologia2017
Hyperglycaemic memory affects the neurovascular unit of the retina in a diabetic mouse model.
Article in Diabetologia, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Single-cell RNA sequencing reveals the dysfunctional characteristics of PBMCs in patients with type 2 diabetes mellitus.Frontiers in immunology · 2024Trial
- Angiogenesis-RNA modification in diabetic retinopathy: biomarkers and targets.International journal of ophthalmology · 2026Article
- Metabolic memory in diabetic complications: evidence for persistent cellular states and limits of therapeutic reversal.Frontiers in endocrinology · 2026Review
- Sex differences in the development of experimental diabetic retinopathy.Scientific reports · 2024Article
- Inter3D: Capture of TAD Reorganization Endows Variant Patterns of Gene Transcription.Genomics, proteomics & bioinformatics · 2024Article
- Specific and shared biological functions of PARP2 - is PARP2 really a lil' brother of PARP1?Expert reviews in molecular medicine · 2024Review
- Microarray Expression Profile of Exosomal circRNAs from High Glucose Stimulated Human Renal Tubular Epithelial Cells.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023Article
- The ideal treatment timing for diabetic retinopathy: the molecular pathological mechanisms underlying early-stage diabetic retinopathy are a matter of concern.Frontiers in endocrinology · 2023Review
- Identifying Suitable Targets for Alzheimer's Disease and Other Eight Common Neurological Disorders Using the Human Plasma Proteome: A Mendelian Randomization Study.Journal of Alzheimer's disease reports · 2023Article
- Hyperglycemic memory in diabetic cardiomyopathy.Frontiers of medicine · 2022Review
- The role of inflammation in immune system of diabetic retinopathy: Molecular mechanisms, pathogenetic role and therapeutic implications.Frontiers in immunology · 2022Review
- Video Analysis and System Construction of Basketball Game by Lightweight Deep Learning under the Internet of Things.Computational intelligence and neuroscience · 2022Article
- Glucose Variability: How Does It Work?International journal of molecular sciences · 2021Review
- Integrative analyses of biomarkers and pathways for adipose tissue after bariatric surgery.Adipocyte · 2020Article
- Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional regulation.Molecular psychiatry · 2020Article
- Therapeutic targeting of trained immunity.Nature reviews. Drug discovery · 2019Review
- Retinal and circulating miRNA expression patterns in diabetic retinopathy: An in silico and in vivo approach.British journal of pharmacology · 2019Article
- Structural and functional damage to the hippocampal neurovascular unit in diabetes-related depression.Neural regeneration research · 2019Article
- Memory effect of arsenic-induced cellular response and its influences on toxicity of titanium dioxide nanoparticle.Scientific reports · 2019Article
- Pathophysiology of Diabetic Retinopathy: The Old and the New.Diabetes & metabolism journal · 2018Review
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aims/hypothesisThe aim of this study was to evaluate damage to the neurovascular unit in a mouse model of hyperglycaemic memory.
methodsA streptozotocin-induced mouse model of diabetes (C57BL/6J background) received insulin-releasing pellets and pancreatic islet-cell transplantation. Damage to the neurovascular unit was studied by quantitative retinal morphometry for microvascular changes and microarray analysis, with subsequent functional annotation clustering, for changes of the retinal genome.
resultsSustained microvascular damage was confirmed by persistent loss of pericytes in the retinal vasculature (PC/mm CONCLUSIONS/
interpretationWe demonstrated that changes in gene expression and microvascular damage persist after euglycaemic re-entry, indicating memory. DATA AVAILABILITY: The datasets generated during and/or analysed during the current study are available in the GEO repository, GSE87433, www.ncbi.nlm.nih.gov/geo/query/acc.cgi?token=idmbysgctluxviv&acc=GSE87433 .
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.