Evidence map›Paper›PMID 28321435›Full record

ReviewNeurogenesis (Austin, Tex.)2017

Amyloid Precursor Protein family as unconventional Go-coupled receptors and the control of neuronal motility.

Jenna M Ramaker, Philip F Copenhaver

Open access · diamondAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neurogenesis (Austin, Tex.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Jenna M RamakerDepartment of Cell, Developmental and Cancer Biology L-215, Oregon Health & Sciences University , Portland, OR, USA.
Philip F CopenhaverDepartment of Cell, Developmental and Cancer Biology L-215, Oregon Health & Sciences University , Portland, OR, USA.
Oregon Health & Science University · US

Funding

Ultrastructure and Single Particle Microscopy CoreP30NS061800 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI AICHER, SUE A · 2009 to 2020
$6.6M
Neuroscience of AgingT32AG023477 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI URBANSKI, HENRYK F · 2005 to 2015
$2.4M
ROLE OF APP-RELATED PROTEINS DURING NEURONAL MIGRATIONR01AG025525 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI COPENHAVER, PHILIP F · 2006 to 2010
$1.4M
Macrophage-dependent regulation of neurotoxic APP fragments in a model systemR21NS078363 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI COPENHAVER, PHILIP F · 2014 to 2015
$424k
NIA NIH HHS R01 AG025525NIA NIH HHS T32 AG023477NINDS NIH HHS P30 NS061800NINDS NIH HHS R21 NS078363
6 · The paper itself

Abstract

Cleavage of the Amyloid Precursor Protein (APP) generates amyloid peptides that accumulate in Alzheimer Disease (AD), but APP is also upregulated by developing and injured neurons, suggesting that it regulates neuronal motility. APP can also function as a G protein-coupled receptor that signals via the heterotrimeric G protein Gαo, but evidence for APP-Gαo signaling

Indexed as

APPAPPLG proteingrowth coneGαohippocampal neuronManducaneuronal migration

Identifiers

PMID28321435
PMCPMC5345750
OpenAlexW2616447747

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.