Evidence map›Paper›PMID 28321389›Full record

ArticleFrontiers in cellular and infection microbiology2017

Host FIH-Mediated Asparaginyl Hydroxylation of Translocated

Christopher Price, Michael Merchant, Snake Jones, Ashley Best, Juanita Von Dwingelo, Matthew B Lawrenz, Nawsad Alam, Ora Schueler-Furman, Yousef A Kwaik

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.1field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Evolution and Adaptation ofBiomolecules · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Christopher PriceDepartment of Microbiology and Immunology, College of Medicine, University of Louisville Louisville, KY, USA.
Michael MerchantDepartment of Medicine-Renal, College of Medicine, University of Louisville Louisville, KY, USA.
Snake JonesDepartment of Microbiology and Immunology, College of Medicine, University of Louisville Louisville, KY, USA.
Ashley BestDepartment of Microbiology and Immunology, College of Medicine, University of Louisville Louisville, KY, USA.
Juanita Von DwingeloDepartment of Microbiology and Immunology, College of Medicine, University of Louisville Louisville, KY, USA.
Matthew B LawrenzDepartment of Microbiology and Immunology, College of Medicine, University of LouisvilleLouisville, KY, USA; Center for Predictive Medicine, College of Medicine, University of LouisvilleLouisville, KY, USA.
Nawsad AlamDepartment of Microbiology and Molecular Genetics, Institute for Medical Research Israel-Canada (IMRIC), Faculty of Medicine, Hadassah Medical School, The Hebrew University of Jerusalem Jerusalem, Israel.
Ora Schueler-FurmanDepartment of Microbiology and Molecular Genetics, Institute for Medical Research Israel-Canada (IMRIC), Faculty of Medicine, Hadassah Medical School, The Hebrew University of Jerusalem Jerusalem, Israel.
Yousef A KwaikDepartment of Microbiology and Immunology, College of Medicine, University of LouisvilleLouisville, KY, USA; Center for Predictive Medicine, College of Medicine, University of LouisvilleLouisville, KY, USA.
University of Louisville · USHebrew University of Jerusalem · IL

Funding

Molecular and Cellular Pathogenesis of LegionellaR01AI120244 · NIAID · UNIVERSITY OF LOUISVILLE · PI ABU KWAIK, YOUSEF A · 2015 to 2019
$1.9M
Exploitation of host glycolysis by LegionellaR21AI116517 · NIAID · UNIVERSITY OF LOUISVILLE · PI ABU KWAIK, YOUSEF A · 2015 to 2016
$413k
NIAID NIH HHS R01 AI120244NIAID NIH HHS R21 AI116517
6 · The paper itself

Abstract

FIH-mediated post-translational modification through asparaginyl hydroxylation of eukaryotic proteins impacts regulation of protein-protein interaction. We have identified the FIH recognition motif in 11

Indexed as

Amino Acid MotifsAsparagineBacterial ProteinsCell LineConsensus SequenceGene Expression Regulation, BacterialHost-Pathogen InteractionsHumansHydroxylationLegionella pneumophilaLegionnaires' DiseaseMicrobial ViabilityMixed Function OxygenasesMutationProtein Processing, Post-TranslationalProtein TransportAsparagineBacterial ProteinsHIF1AN protein, humanMixed Function OxygenasesRepressor ProteinsUbiquitinAnkBankyrinasparagine hydroxylationbacterial pathogenesisDot/IcmFIHhypoxia-inducible factor (HIF)Legionella

Identifiers

PMID28321389
PMCPMC5337513
OpenAlexW2594413201

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.