ArticleDose-response : a publication of International Hormesis Society
Evidence That Lifelong Low Dose Rates of Ionizing Radiation Increase Lifespan in Long- and Short-Lived Dogs.
Article in Dose-response : a publication of International Hormesis Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed.
- Expansion of monocytic myeloid-derived suppressor cells ameliorated intestinal inflammatory response by radiation through SOCS3 expression.Cell death & disease · 2021Article
- Low-dose ionizing radiation as a hormetin: experimental observations and therapeutic perspective for age-related disorders.Biogerontology · 2021Review
- Low-Dose Radiation to COVID-19 Patients to Ease the Disease Course and Reduce the Need of Intensive Care.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2020Article
- Regulating Ionizing Radiation Based on Metrics for Evaluation of Regulatory Science Claims.Dose-response : a publication of International Hormesis SocietyArticle
- The Lowest Radiation Dose Having Molecular Changes in the Living Body.Dose-response : a publication of International Hormesis SocietyArticle
- X-Ray Imaging is Essential for Contemporary Chiropractic and Manual Therapy Spinal Rehabilitation: Radiography Increases Benefits and Reduces Risks.Dose-response : a publication of International Hormesis SocietyArticle
- Evidence of a Dose-Rate Threshold for Life Span Reduction of Dogs Exposed Lifelong to γ-Radiation.Dose-response : a publication of International Hormesis SocietyArticle
- Necrotizing Fasciitis: Low-Dose Radiotherapy as a Potential Adjunct Treatment.Dose-response : a publication of International Hormesis SocietyReview
- X-Ray Hesitancy: Patients' Radiophobic Concerns Over Medical X-rays.Dose-response : a publication of International Hormesis SocietyArticle
- Response to Commentary: Treating Alzheimer Dementia With CT-Induced Low-Dose Ionizing Radiation: Problematic, Yet Potential for More Precise Inquiry.Dose-response : a publication of International Hormesis SocietyArticle
- Treatment of Early-Stage Alzheimer's Disease With CT Scans of the Brain: A Case Report.Dose-response : a publication of International Hormesis SocietyArticle
- Continuous Low-Dose-Rate Irradiation Promotes Growth of Silkworms.Dose-response : a publication of International Hormesis SocietyArticle
- Present and Future Prospects of Radiation Therapy Using α-Emitting Nuclides.Dose-response : a publication of International Hormesis SocietyArticle
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
After the 1956 radiation scare to stop weapons testing, studies focused on cancer induction by low-level radiation. Concern has shifted to protecting "radiation-sensitive individuals." Since longevity is a measure of health impact, this analysis reexamined data to compare the effect of dose rate on the lifespans of short-lived (5% and 10% mortality) dogs and on the lifespans of dogs at 50% mortality. The data came from 2 large-scale studies. One exposed 10 groups to different γ dose rates; the other exposed 8 groups to different lung burdens of plutonium. Reexamination indicated that normalized lifespans increased more for short-lived dogs than for average dogs, when radiation was moderately above background. This was apparent by interpolating between the lifespans of nonirradiated dogs and exposed dogs. The optimum lifespan increase appeared at 50 mGy/y. The threshold for harm (decreased lifespan) was 700 mGy/y for 50% mortality dogs and 1100 mGy/y for short-lived dogs. For inhaled α-emitting particulates, longevity was remarkably increased for short-lived dogs below the threshold for harm. Short-lived dogs seem more radiosensitive than average dogs and they benefit more from low radiation. If dogs model humans, this evidence would support a change to radiation protection policy. Maintaining exposures "as low as reasonably achievable" (ALARA) appears questionable.
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