Evidence map›Paper›PMID 28321014›Full record

ArticleJournal of atherosclerosis and thrombosis2017

Homogeneous Assays for LDL-C and HDL-C are Reliable in Both the Postprandial and Fasting State.

Takashi Miida, Kunihiro Nishimura, Satoshi Hirayama, Yoshihiro Miyamoto, Masakazu Nakamura, Daisaku Masuda, Shizuya Yamashita, Masaji Ushiyama, Toshiaki Komori, Naohisa Fujita and 2 more

Open access · diamondAbstract read
In one paragraph

Article in Journal of atherosclerosis and thrombosis, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
5.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.

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  8. Global Standardization of Lipid/Lipoprotein Testing.Juntendo Iji zasshi = Juntendo medical journal · 2024
    Article
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  15. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 2 countries.

Takashi MiidaDepartment of Clinical Laboratory Medicine, Juntendo University Graduate School of Medicine.
Kunihiro NishimuraDepartment of Preventive Medicine and Epidemiologic Informatics, National Cerebral and Cardiovascular Center.
Satoshi HirayamaDepartment of Clinical Laboratory Medicine, Juntendo University Graduate School of Medicine.
Yoshihiro MiyamotoDepartment of Preventive Cardiology, Department of Preventive Medicine and Epidemiologic Informatics, National Cerebral and Cardiovascular Center.
Masakazu NakamuraDepartment of Preventive Cardiology, Lipid Reference Laboratory, National Cerebral and Cardiovascular Center.
Daisaku MasudaDepartment of Cardiovascular Medicine, Osaka University Graduate School of Medicine.
Shizuya YamashitaDepartment of Cardiovascular Medicine, Osaka University Graduate School of Medicine.
Masaji UshiyamaClinical Laboratory, University Hospital, Kyoto Prefectural University of Medicine.
Toshiaki KomoriClinical Laboratory, University Hospital, Kyoto Prefectural University of Medicine.
Naohisa FujitaDepartment of Infection Control and Laboratory Medicine, Kyoto Prefectural University of Medicine.
Shinji YokoyamaDepartment of Food and Nutritional Sciences, Practice Center for Registered Dietitian, Chubu University.
Tamio TeramotoTeikyo Academic Research Center, Teikyo University.
National Cerebral and Cardiovascular Center · JPJuntendo University · JPOsaka University · JPUniversity Hospital Kyoto Prefectural University of Medicine · JPChubu University · JPKyoto Prefectural University of Medicine · JPTeikyo University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimMost epidemiological and clinical studies calculated low-density lipoprotein-cholesterol (LDL-C) by Friedewald's formula which cannot be used in the postprandial samples. Although the homogeneous assays with poor analytical performance were withdrawn from the market, it remained unclear whether the currently available reagents for LDL-C and high-density lipoprotein-cholesterol (HDL-C) are as accurate for postprandial samples as for fasting samples.

methodsFresh blood samples were collected from 59 non-diseased and 109 diseased subjects. Postprandial samples constituted 72.9% and 39.4% of these samples. LDL-C and HDL-C concentrations were measured using the homogeneous assays of four manufacturers (Denka Seiken, Wako, Kyowa Medex, and Sekisui Medical). Simultaneously, LDL-C and HDL-C concentrations were determined using the reference measurement procedures (RMPs) of the Centers for Disease Control and Prevention (CDC). Total errors were calculated using a routine method (TE

resultsAll homogeneous assays for LDL-C and HDL-C met the National Cholesterol Education Program (NCEP) requirements in terms of coefficient of variation, and TE

conclusionsIn both non-diseased and diseased subjects, the homogeneous assays for LDL-C and HDL-C of four manufacturers are as accurate for postprandial samples as for fasting samples.

Indexed as

FastingPostprandial PeriodAdultAgedCalibrationCase-Control StudiesCholesterol, HDLCholesterol, LDLClinical Laboratory TechniquesFemaleHumansMaleMiddle AgedModels, StatisticalOutpatientsReproducibility of ResultsCholesterol, HDLCholesterol, LDLTriglyceridesCholesterol Reference Method Laboratory Network (CRMLN)Direct assayDyslipidemiaFriedewald's formulaStandardization

Identifiers

PMID28321014
PMCPMC5453684
OpenAlexW2595615483

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.