Evidence map›Paper›PMID 28320896›Full record

ArticlePhysiological reports2017

Estrogen maintains mitochondrial content and function in the right ventricle of rats with pulmonary hypertension.

Aiping Liu, Jennifer Philip, Kalyan C Vinnakota, Francoise Van den Bergh, Diana M Tabima, Timothy Hacker, Daniel A Beard, Naomi C Chesler

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 1 pooled it
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. New Drugs and Therapies in Pulmonary Arterial Hypertension.International journal of molecular sciences · 2023
    Review
  11. Review
  12. Review
  13. Sex and gender in pulmonary arterial hypertension.European respiratory review : an official journal of the European Respiratory Society · 2021
    Review
  14. Review
  15. Review
  16. Review
  17. Article
  18. Cardioprotection in right heart failure.British journal of pharmacology · 2020
    Review
  19. Review
  20. Estrogen receptor-α prevents right ventricular diastolic dysfunction and fibrosis in female rats.American journal of physiology. Heart and circulatory physiology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Aiping LiuDepartment of Biomedical Engineering, University of Wisconsin-Madison, Madison, Wisconsin.
Jennifer PhilipDepartment of Biomedical Engineering, University of Wisconsin-Madison, Madison, Wisconsin.
Kalyan C VinnakotaDepartment of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, Michigan.
Francoise Van den BerghDepartment of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, Michigan.
Diana M TabimaDepartment of Biomedical Engineering, University of Wisconsin-Madison, Madison, Wisconsin.
Timothy HackerDepartment of Medicine, University of Wisconsin-Madison, Madison, Wisconsin.
Daniel A BeardDepartment of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, Michigan.
Naomi C CheslerDepartment of Biomedical Engineering, University of Wisconsin-Madison, Madison, Wisconsin naomi.chesler@wisc.edu.
University of Wisconsin–Madison · USUniversity of Michigan–Ann Arbor · US

Funding

Vascular collagen accumulation & mechanical mechanisms in pulmonary hypertensionR01HL086939 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI CHESLER, NAOMI C · 2007 to 2016
$3.6M
Vascular Surgery Research Training ProgramT32HL110853 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI MATSUMURA, JON STEVEN · 2012 to 2021
$2.6M
6 · The paper itself

Abstract

The typical cause of death in pulmonary hypertension (PH) is right ventricular (RV) failure, with females showing better survival rates than males. Recently, metabolic shift and mitochondrial dysfunction have been demonstrated in RV failure secondary to PH In light of evidence showing that estrogen protects mitochondrial function and biogenesis in noncardiovascular systems, we hypothesized that the mechanism by which estrogen preserves RV function is via protection of mitochondrial content and oxidative capacity in PH We used a well-established model of PH (Sugen+Hypoxia) in ovariectomized female rats with/without estrogen treatment. RV functional measures were derived from pressure-volume relationships measured via RV catheterization in live rats. Citrate synthase activity, a marker of mitochondrial density, was measured in both RV and LV tissues. Respiratory capacity of mitochondria isolated from RV was measured using oxygraphy. We found that RV ventricular-vascular coupling efficiency decreased in the placebo-treated SuHx rats (0.78 ± 0.10 vs. 1.50 ± 0.13 in control,

Indexed as

AnimalsEstradiolFemaleHeart VentriclesHypertension, PulmonaryMitochondriaOrganelle BiogenesisOvariectomyOxidation-ReductionRatsRats, Sprague-DawleyVentricular Function, RightEstradiolCardiopulmonary hemodynamicsmitochondriasex differences

Identifiers

PMID28320896
PMCPMC5371553
OpenAlexW2603460820

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.