Evidence map›Paper›PMID 28320859›Full record

ArticleThe Journal of biological chemistry2017

2-Arachidonoylglycerol ameliorates inflammatory stress-induced insulin resistance in cardiomyocytes.

Dipanjan Chanda, Yvonne Oligschlaeger, Ilvy Geraets, Yilin Liu, Xiaoqing Zhu, Jieyi Li, Miranda Nabben, Will Coumans, Joost J F P Luiken, Jan F C Glatz and 1 more

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 39 citations in OpenAlex.

  1. Article
  2. Article
  3. Guayusa (Molecules (Basel, Switzerland) · 2025
    Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Guidelines on models of diabetic heart disease.American journal of physiology. Heart and circulatory physiology · 2022
    Review
  9. Review
  10. Article
  11. Review
  12. Article
  13. Review
  14. Insulin signaling in the heart.American journal of physiology. Endocrinology and metabolism · 2021
    Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Dipanjan ChandaFrom the Department of Molecular Genetics, CARIM School for Cardiovascular Diseases, Maastricht University, 6200 MD Maastricht, The Netherlands d.chanda@maastrichtuniversity.nl.ORCID 0000-0003-0685-187X
Yvonne OligschlaegerFrom the Department of Molecular Genetics, CARIM School for Cardiovascular Diseases, Maastricht University, 6200 MD Maastricht, The Netherlands.
Ilvy GeraetsFrom the Department of Molecular Genetics, CARIM School for Cardiovascular Diseases, Maastricht University, 6200 MD Maastricht, The Netherlands.
Yilin LiuFrom the Department of Molecular Genetics, CARIM School for Cardiovascular Diseases, Maastricht University, 6200 MD Maastricht, The Netherlands.
Xiaoqing ZhuFrom the Department of Molecular Genetics, CARIM School for Cardiovascular Diseases, Maastricht University, 6200 MD Maastricht, The Netherlands.
Jieyi LiFrom the Department of Molecular Genetics, CARIM School for Cardiovascular Diseases, Maastricht University, 6200 MD Maastricht, The Netherlands.
Miranda NabbenFrom the Department of Molecular Genetics, CARIM School for Cardiovascular Diseases, Maastricht University, 6200 MD Maastricht, The Netherlands.
Will CoumansFrom the Department of Molecular Genetics, CARIM School for Cardiovascular Diseases, Maastricht University, 6200 MD Maastricht, The Netherlands.
Joost J F P LuikenFrom the Department of Molecular Genetics, CARIM School for Cardiovascular Diseases, Maastricht University, 6200 MD Maastricht, The Netherlands.
Jan F C GlatzFrom the Department of Molecular Genetics, CARIM School for Cardiovascular Diseases, Maastricht University, 6200 MD Maastricht, The Netherlands.
Dietbert NeumannFrom the Department of Molecular Genetics, CARIM School for Cardiovascular Diseases, Maastricht University, 6200 MD Maastricht, The Netherlands.
Maastricht University · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several studies have linked impaired glucose uptake and insulin resistance (IR) to functional impairment of the heart. Recently, endocannabinoids have been implicated in cardiovascular disease. However, the mechanisms involving endocannabinoid signaling, glucose uptake, and IR in cardiomyocytes are understudied. Here we report that the endocannabinoid 2-arachidonoylglycerol (2-AG), via stimulation of cannabinoid type 1 (CB1) receptor and Ca

Indexed as

Insulin ResistanceAMP-Activated Protein KinasesAnimalsAnti-Inflammatory AgentsArachidonic AcidsCalcium-Calmodulin-Dependent Protein Kinase KinaseCell DifferentiationDiabetes Mellitus, ExperimentalEmbryonic Stem CellsEndocannabinoidsGlucoseGlucose Transporter Type 4GlyceridesGlycogenHumansInflammationAMP-Activated Protein KinasesAnti-Inflammatory AgentsArachidonic AcidsCalcium-Calmodulin-Dependent Protein Kinase KinaseEndocannabinoidsGlucoseGlucose Transporter Type 4Glyceridesglyceryl 2-arachidonateGlycogenReceptor, Cannabinoid, CB1RNA, MessengerSlc2a4 protein, mouseTumor Necrosis Factor-alphaAMP-activated kinase (AMPK)cell signalingendocannabinoidglucose transporter type 4 (GLUT4)glucose uptakeinflammationinsulin resistance

Identifiers

PMID28320859
PMCPMC5409477
OpenAlexW2599165038

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.