Evidence map›Paper›PMID 28320836›Full record

ArticleInfection and immunity2017

Adaptive Upregulation of Clumping Factor A (ClfA) by Staphylococcus aureus in the Obese, Type 2 Diabetic Host Mediates Increased Virulence.

Christopher W Farnsworth, Eric M Schott, Sarah E Jensen, Jacob Zukoski, Abigail M Benvie, Majed A Refaai, Stephen L Kates, Edward M Schwarz, Michael J Zuscik, Steven R Gill and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Infection and immunity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 51 citations in OpenAlex.

  1. Review
  2. Methicillin-resistant Staphylococcus aureus.Nature reviews. Disease primers · 2026
    Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Fracture-related infection.Nature reviews. Disease primers · 2022
    Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. In Vitro 3DPathogens (Basel, Switzerland) · 2021
    Article
  16. Article
  17. International journal of molecular sciences · 2021
    Review
  18. Functional Insights of MraZ on the Pathogenicity ofInfection and drug resistance · 2021
    Article
  19. Frontiers in microbiology · 2021
    Article
  20. Three-DimensionalInfection and immunity · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Christopher W FarnsworthDepartment of Pathology & Laboratory Medicine, University of Rochester, Rochester, New York, USA.
Eric M SchottDepartment of Pathology & Laboratory Medicine, University of Rochester, Rochester, New York, USA.
Sarah E JensenDepartment of Pathology & Laboratory Medicine, University of Rochester, Rochester, New York, USA.
Jacob ZukoskiDepartment of Pathology & Laboratory Medicine, University of Rochester, Rochester, New York, USA.
Abigail M BenvieCenter for Musculoskeletal Research, University of Rochester, Rochester, New York, USA.
Majed A RefaaiDepartment of Pathology & Laboratory Medicine, University of Rochester, Rochester, New York, USA.
Stephen L KatesDepartment of Orthopaedic Surgery, Virginia Commonwealth University, Richmond, Virginia, USA.
Edward M SchwarzCenter for Musculoskeletal Research, University of Rochester, Rochester, New York, USA.
Michael J ZuscikCenter for Musculoskeletal Research, University of Rochester, Rochester, New York, USA.
Steven R GillDepartment of Microbiology and Immunology, University of Rochester, Rochester, New York, USA.
Robert A MooneyDepartment of Pathology & Laboratory Medicine, University of Rochester, Rochester, New York, USA robert_mooney@urmc.rochester.edu.
University of Rochester · USVirginia Commonwealth University · US

Funding

The University of Rochester's Clinical and Translational Science InstituteUL1TR002001 · NCATS · UNIVERSITY OF ROCHESTER · PI WILSON, KAREN M., ZAND, MARTIN S · 2016 to 2024
$34.6M
Rochester Resource-Based Center for Bone, Muscle and Orthopaedic Research (ROCSTARR) (Overall Application)P30AR069655 · NIAMS · UNIVERSITY OF ROCHESTER · PI Edward M. Schwarz · 2016 to 2026
$7.8M
Training in Orthopaedic Researchhttps://apps.era.nih.gov/grantfolder/viewInternalGF.era?applId=8841318&folderId=90T32AR053459 · NIAMS · UNIVERSITY OF ROCHESTER · PI ZUSCIK, MICHAEL J · 2006 to 2017
$3.4M
The University of Rochester Clinical and Translational Science InstituteTL1TR000096 · NCATS · UNIVERSITY OF ROCHESTER · PI BENNETT, NANCY M, KIEBURTZ, KARL D. · 2012 to 2015
$930k
NCATS NIH HHS TL1 TR000096NCATS NIH HHS UL1 TR002001NIAMS NIH HHS P30 AR069655NIAMS NIH HHS T32 AR053459
6 · The paper itself

Abstract

Obesity and associated type 2 diabetes (T2D) are important risk factors for infection following orthopedic implant surgery.

Indexed as

AbscessAnimalsAntibodies, BacterialCoagulaseDiabetes Mellitus, Type 2Disease Models, AnimalFibrinogenHumansMaleMiceMice, Inbred C57BLObesityOsteomyelitisSequence Analysis, RNAStaphylococcal InfectionsTranscriptional ActivationAntibodies, BacterialClfA protein, Staphylococcus aureusCoagulaseFibrinogenclumping factor AfibrinogenobesityosteomyelitisStaphylococcus aureustype 2 diabetes

Identifiers

PMID28320836
PMCPMC5442639
OpenAlexW2598543181

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.