Evidence map›Paper›PMID 28320833›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2017

Inflammatory Changes in Bone Marrow Microenvironment Associated with Declining B Lymphopoiesis.

Domenick E Kennedy, Katherine L Knight

Abstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 43 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
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  6. Pathology of Diabetes-Induced Immune Dysfunction.International journal of molecular sciences · 2024
    Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Adipose tissue and hematopoiesis: Friend or foe?Journal of clinical laboratory analysis · 2023
    Review
  12. Article
  13. Review
  14. Review
  15. Review
  16. Article
  17. Review
  18. Review
  19. Article
  20. Do haematopoietic stem cells age?Nature reviews. Immunology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Domenick E KennedyDepartment of Microbiology and Immunology, Loyola University, Chicago, IL 60153.
Katherine L KnightDepartment of Microbiology and Immunology, Loyola University, Chicago, IL 60153 kknight@luc.edu.
Loyola University Chicago · US

Funding

Experimental Immunology Training GrantT32AI007508 · NIAID · LOYOLA UNIVERSITY CHICAGO · PI KNIGHT, KATHERINE L. · 1997 to 2022
$4.0M
Maintaining B cell immunity with aged B lymphocytesR01AI068390 · NIAID · LOYOLA UNIVERSITY CHICAGO · PI KNIGHT, KATHERINE L. · 2007 to 2015
$3.4M
Decline of B lymphopoiesis with Age: Adipocytes and Myeloid Suppressor CellsF31AG047817 · NIA · LOYOLA UNIVERSITY CHICAGO · PI KENNEDY, DOMENICK EDWARD · 2014 to 2015
$57k
NIAID NIH HHS R01 AI068390NIAID NIH HHS T32 AI007508NIA NIH HHS F31 AG047817
6 · The paper itself

Abstract

B lymphopoiesis arrests precipitously in rabbits such that by 2-4 mo of age, before sexual maturity, little to no B lymphopoiesis occurs in the bone marrow (BM). Previously, we showed that in mice, adipocytes inhibit B lymphopoiesis in vitro by inducing inflammatory myeloid cells, which produce IL-1β. In this study, we characterized rabbit BM after the arrest of B lymphopoiesis and found a dramatic increase in fat, increased CD11b

Indexed as

Cellular MicroenvironmentAdipose TissueAnimalsB-LymphocytesBone Marrow CellsCalgranulin BCD11b AntigenCells, CulturedGlyburideInterleukin-1betaLymphopoiesisMiceMyelopoiesisNLR Family, Pyrin Domain-Containing 3 ProteinRabbitsCalgranulin BCD11b AntigenGlyburideInterleukin-1betaNLR Family, Pyrin Domain-Containing 3 Protein

Identifiers

PMID28320833
PMCPMC5435233
OpenAlexW2614898092

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.