Evidence map›Paper›PMID 28320824›Full record

ArticleThe Journal of cell biology2017

Molecular mechanism of dynein recruitment to kinetochores by the Rod-Zw10-Zwilch complex and Spindly.

José B Gama, Cláudia Pereira, Patrícia A Simões, Ricardo Celestino, Rita M Reis, Daniel J Barbosa, Helena R Pires, Cátia Carvalho, João Amorim, Ana X Carvalho and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of cell biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers.

0numbers the graph read from it
0cells of the map it votes in
94citing papers in PubMed
8.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

94 citing papers in PubMed, 149 citations in OpenAlex.

  1. Article
  2. Structure and function of the outer kinetochore.Nature reviews. Molecular cell biology · 2026
    Review
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  8. Review
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  13. Occludin acts as a dynein adaptor regulating permeability and collateral angiogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  14. Article
  15. Article
  16. Article
  17. World journal of gastrointestinal oncology · 2025
    Article
  18. Article
  19. Review
  20. Article

34 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

José B GamaInstituto de Biologia Molecular e Celular, Universidade do Porto, 4200-135 Porto, Portugal.ORCID 0000-0002-7011-1502
Cláudia PereiraInstituto de Biologia Molecular e Celular, Universidade do Porto, 4200-135 Porto, Portugal.ORCID 0000-0001-8050-5102
Patrícia A SimõesInstituto de Biologia Molecular e Celular, Universidade do Porto, 4200-135 Porto, Portugal.ORCID 0000-0003-3097-5119
Ricardo CelestinoInstituto de Biologia Molecular e Celular, Universidade do Porto, 4200-135 Porto, Portugal.ORCID 0000-0002-9605-6433
Rita M ReisInstituto de Biologia Molecular e Celular, Universidade do Porto, 4200-135 Porto, Portugal.ORCID 0000-0003-0937-8045
Daniel J BarbosaInstituto de Biologia Molecular e Celular, Universidade do Porto, 4200-135 Porto, Portugal.ORCID 0000-0002-1726-6011
Helena R PiresInstituto de Biologia Molecular e Celular, Universidade do Porto, 4200-135 Porto, Portugal.ORCID 0000-0001-8351-0812
Cátia CarvalhoInstituto de Biologia Molecular e Celular, Universidade do Porto, 4200-135 Porto, Portugal.
João AmorimInstituto de Biologia Molecular e Celular, Universidade do Porto, 4200-135 Porto, Portugal.
Ana X CarvalhoInstituto de Biologia Molecular e Celular, Universidade do Porto, 4200-135 Porto, Portugal.ORCID 0000-0002-2256-7134
Dhanya K CheerambathurLudwig Institute for Cancer Research, University of California, San Diego, La Jolla, CA 92093.
Reto GassmannInstituto de Biologia Molecular e Celular, Universidade do Porto, 4200-135 Porto, Portugal rgassmann@ibmc.up.pt.ORCID 0000-0002-0360-2977
Universidade do Porto · PTUniversity of California San Diego · US

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
NIH HHS P40 OD010440
6 · The paper itself

Abstract

The molecular motor dynein concentrates at the kinetochore region of mitotic chromosomes in animals to accelerate spindle microtubule capture and to control spindle checkpoint signaling. In this study, we describe the molecular mechanism used by the Rod-Zw10-Zwilch complex and the adaptor Spindly to recruit dynein to kinetochores in

Indexed as

AnimalsCaenorhabditis elegansCarrier ProteinsCell Cycle ProteinsCell Line, TumorChromosomal Proteins, Non-HistoneChromosome SegregationDynactin ComplexDyneinsHeLa CellsHumansKinetochoresMicrotubule-Associated ProteinsMicrotubulesMitosisSpindle ApparatusCarrier ProteinsCell Cycle ProteinsChromosomal Proteins, Non-HistoneDynactin ComplexDyneinsMicrotubule-Associated ProteinsBICD2dynein/dynactinkinetochoremitosisRZZ complexSpindly

Identifiers

PMID28320824
PMCPMC5379953
OpenAlexW2602823966

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.