Evidence map›Paper›PMID 28320767›Full record

ArticleJournal of the American Society of Nephrology : JASN2017

Comparing Outcomes between Antibody Induction Therapies in Kidney Transplantation.

Neel Koyawala, Jeffrey H Silber, Paul R Rosenbaum, Wei Wang, Alexander S Hill, Joseph G Reiter, Bijan A Niknam, Orit Even-Shoshan, Roy D Bloom, Deirdre Sawinski and 5 more

Open access · bronzeAbstract readComparative Study
In one paragraph

Article in Journal of the American Society of Nephrology : JASN, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.

  1. Pooled it
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  7. Review
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  12. Imlifidase in kidney transplantation.Clinical kidney journal · 2024
    Article
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  15. Imlifidase for Kidney Transplantation of Highly Sensitized Patients With a Positive Crossmatch: The French Consensus Guidelines.Transplant international : official journal of the European Society for Organ Transplantation · 2023
    Article
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  17. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Neel KoyawalaSchool of Arts and Sciences and.
Jeffrey H SilberCenter for Outcomes Research, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Paul R RosenbaumDepartment of Statistics, Wharton School, University of Pennsylvania, Philadelphia, Pennsylvania.
Wei WangCenter for Outcomes Research, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Alexander S HillCenter for Outcomes Research, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Joseph G ReiterCenter for Outcomes Research, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Bijan A NiknamCenter for Outcomes Research, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Orit Even-ShoshanCenter for Outcomes Research, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Roy D BloomRenal Electrolyte and Hypertension Division, Department of Medicine, and.
Deirdre SawinskiRenal Electrolyte and Hypertension Division, Department of Medicine, and.
Susanna NazarianDepartments of Surgery and.
Jennifer Trofe-ClarkRenal Electrolyte and Hypertension Division, Department of Medicine, and.
Mary Ann LimRenal Electrolyte and Hypertension Division, Department of Medicine, and.
Jesse D ScholdDepartment of Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio.
Peter P ReeseRenal Electrolyte and Hypertension Division, Department of Medicine, and peter.reese@uphs.upenn.edu.
Children's Hospital of Philadelphia · USUniversity of Pennsylvania · USCleveland Clinic · USHospital of the University of Pennsylvania · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Kidney transplant recipients often receive antibody induction. Previous studies of induction therapy were often limited by short follow-up and/or absence of information about complications. After linking Organ Procurement and Transplantation Network data with Medicare claims, we compared outcomes between three induction therapies for kidney recipients. Using novel matching techniques developed on the basis of 15 clinical and demographic characteristics, we generated 1:1 pairs of alemtuzumab-rabbit antithymocyte globulin (rATG) (5330 pairs) and basiliximab-rATG (9378 pairs) recipients. We used paired Cox regression to analyze the primary outcomes of death and death or allograft failure. Secondary outcomes included death or sepsis, death or lymphoma, death or melanoma, and healthcare resource utilization within 1 year. Compared with rATG recipients, alemtuzumab recipients had higher risk of death (hazard ratio [HR], 1.14; 95% confidence interval [95% CI], 1.03 to 1.26;

Indexed as

Kidney TransplantationAgedAged, 80 and overAlemtuzumabAnimalsAntibodiesAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedAntilymphocyte SerumBasiliximabCohort StudiesFemaleHumansImmunosuppressive AgentsMaleMiddle AgedAlemtuzumabAntibodiesAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedAntilymphocyte SerumBasiliximabImmunosuppressive AgentsRecombinant Fusion Proteinsacute rejectioncancerimmunosuppressionsurvivaltransplant outcomes

Identifiers

PMID28320767
PMCPMC5491281
OpenAlexW2602159146

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.