Evidence map›Paper›PMID 28320755›Full record

ReviewCold Spring Harbor perspectives in biology2017

Ciliary Mechanisms of Cyst Formation in Polycystic Kidney Disease.

Ming Ma, Anna-Rachel Gallagher, Stefan Somlo

Open access · bronzeAbstract readReview
In one paragraph

Review in Cold Spring Harbor perspectives in biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

81 citing papers in PubMed, 133 citations in OpenAlex.

  1. Broadening horizons: Pathogenesis and therapeutics of renal ciliopathies.Journal of cell communication and signaling · 2026
    Review
  2. Review
  3. Exploring multiple drug actions of a CaNaunyn-Schmiedeberg's archives of pharmacology · 2026
    Review
  4. Review
  5. Article
  6. Article
  7. Inhibition of the inflammasome ameliorates orthologous polycystic kidney disease.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Review
  14. Pathogenic variants in the polycystin pore helix cause distinct forms of channel dysfunction.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  15. Review
  16. Article
  17. Ciliary G-Protein Coupled Receptor Signaling in Polycystic Kidney Disease.International journal of molecular sciences · 2025
    Review
  18. Article
  19. Article
  20. Article

21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Ming MaDepartment of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520-8029.
Anna-Rachel GallagherDepartment of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520-8029.
Stefan SomloDepartment of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520-8029.
Yale University · US

Funding

GENETICS OF AUTOSOMAL DOMINANT POLYCYSTIC LIVER DISEASER01DK051041 · NIDDK · YESHIVA UNIVERSITY · PI SOMLO, STEFAN · 1995 to 2010
$3.4M
MOUSE MODELS OF POLYCYSTIC KIDNEY DISEASE (PKD2)R01DK054053 · NIDDK · YESHIVA UNIVERSITY · PI SOMLO, STEFAN · 1998 to 2015
$3.2M
Mechanisms of Polycystin and Cilia Function in ADPKDR01DK100592 · NIDDK · YALE UNIVERSITY · PI SOMLO, STEFAN · 2013 to 2017
$1.8M
NIDDK NIH HHS R01 DK051041NIDDK NIH HHS R01 DK054053NIDDK NIH HHS R01 DK100592
6 · The paper itself

Abstract

Autosomal-dominant polycystic kidney disease (ADPKD) is a disease of defective tissue homeostasis resulting in active remodeling of nephrons and bile ducts to form fluid-filled sacs called cysts. The causal genes

Indexed as

AnimalsCiliaCystsHedgehog ProteinsHomeostasisHumansPolycystic Kidney, Autosomal DominantSignal TransductionHedgehog Proteins

Identifiers

PMID28320755
PMCPMC5666631
OpenAlexW2598474916

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.