Evidence map›Paper›PMID 28320741›Full record

ArticleThe EMBO journal2017

Hypoxia enhances antibody-dependent dengue virus infection.

Esther Shuyi Gan, Wei Fun Cheong, Kuan Rong Chan, Eugenia Ziying Ong, Xiaoran Chai, Hwee Cheng Tan, Sujoy Ghosh, Markus R Wenk, Eng Eong Ooi

Open access · hybridAbstract read
In one paragraph

Article in The EMBO journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Roles of endothelial cells during infection.Current opinion in immunology · 2025
    Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Oxygen: viral friend or foe?Virology journal · 2020
    Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Esther Shuyi GanProgramme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore.
Wei Fun CheongDepartment of Biochemistry, National University of Singapore, Singapore, Singapore.
Kuan Rong ChanProgramme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore.
Eugenia Ziying OngProgramme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore.ORCID 0000-0003-2187-7058
Xiaoran ChaiProgram in Cardiovascular & Metabolic Disorders and Centre for Computational Biology, Duke-NUS Medical School, Singapore, Singapore.
Hwee Cheng TanProgramme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore.
Sujoy GhoshProgram in Cardiovascular & Metabolic Disorders and Centre for Computational Biology, Duke-NUS Medical School, Singapore, Singapore.
Markus R WenkDepartment of Biochemistry, National University of Singapore, Singapore, Singapore.
Eng Eong OoiProgramme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore engeong.ooi@duke-nus.edu.sg.ORCID 0000-0002-0520-1544
Duke-NUS Medical School · SGNational University of Singapore · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dengue virus (DENV) has been found to replicate in lymphoid organs such as the lymph nodes, spleen, and liver in post-mortem analysis. These organs are known to have low oxygen levels (~0.5-4.5% O

Indexed as

Antibody-Dependent EnhancementHypoxiaAntibodies, ViralCell MembraneCells, CulturedDengueDengue VirusHumansHypoxia-Inducible Factor 1, alpha SubunitLipid MetabolismMonocytesReceptors, IgGAntibodies, ViralFc gamma receptor IIAHIF1A protein, humanHypoxia-Inducible Factor 1, alpha SubunitReceptors, IgGantibody‐dependent enhancementcellular lipidsdengueFc receptorshypoxia

Identifiers

PMID28320741
PMCPMC5430213
OpenAlexW2603135017

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.