Evidence map›Paper›PMID 28320712›Full record

ArticleAntimicrobial agents and chemotherapy2017

Efficacy of Telavancin Alone and in Combination with Ampicillin in a Rat Model of Enterococcus faecalis Endocarditis.

Truc T Tran, Vincent H Tam, Barbara E Murray, Cesar A Arias, Kavindra V Singh

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Truc T TranDivision of Infectious Diseases, Department of Internal Medicine, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
Vincent H TamCollege of Pharmacy, University of Houston, Houston, Texas, USA.
Barbara E MurrayDivision of Infectious Diseases, Department of Internal Medicine, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
Cesar A AriasDivision of Infectious Diseases, Department of Internal Medicine, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
Kavindra V SinghDivision of Infectious Diseases, Department of Internal Medicine, The University of Texas Health Science Center at Houston, Houston, Texas, USA kavindra.singh@uth.tmc.edu.
The University of Texas Health Science Center at Houston · USUniversidad El Bosque · COUniversity of Houston · US

Funding

Daptomycin Resistance in Enterococcus faeciumK08AI113317 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI TRAN, TRUC THANH · 2014 to 2018
$792k
Targeting Cell Membrane Adaptation in Multidrug-Resistant Enterococcus faeciumR21AI121519 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ARIAS, CESAR AUGUSTO · 2016 to 2017
$226k
NIAID NIH HHS K08 AI113317NIAID NIH HHS R21 AI121519
6 · The paper itself

Abstract

We first assessed telavancin (TLV) pharmacokinetics in rats after a single subcutaneous dose of 35 mg/kg of body weight. The pharmacokinetic data were used to predict a TLV dose that simulates human exposure, and the efficacy of TLV was then evaluated using a TLV dose of 21 mg/kg every 12 h against

Indexed as

AminoglycosidesAmpicillinAnimalsAnti-Bacterial AgentsCeftriaxoneCephalosporinsDaptomycinDrug Therapy, CombinationEndocarditis, BacterialEnterococcus faecalisGentamicinsLipoglycopeptidesMaleMicrobial Sensitivity TestsRatsRats, Sprague-DawleyAminoglycosidesAmpicillinAnti-Bacterial AgentsCeftriaxoneCephalosporinsDaptomycinGentamicinsLipoglycopeptidestelavancinVancomycinEnterococcus faecalisrat endocarditistelavancintherapy

Identifiers

PMID28320712
PMCPMC5444151
OpenAlexW2599898848

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.