Evidence map›Paper›PMID 28320468›Full record

ArticleMicrobiome2017

Subgingival microbiota dysbiosis in systemic lupus erythematosus: association with periodontal status.

Jôice Dias Corrêa, Débora Cerqueira Calderaro, Gilda Aparecida Ferreira, Santuza Maria Souza Mendonça, Gabriel R Fernandes, E Xiao, Antônio Lúcio Teixeira, Eugene J Leys, Dana T Graves, Tarcília Aparecida Silva

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiome, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
97citing papers in PubMed, 5 pooled it
11.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

97 citing papers in PubMed, 5 syntheses or guidelines pooled it, 171 citations in OpenAlex.

  1. Pooled it
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  9. Salivary Immune and Endocrine Biomarkers in Skin and Mucocutaneous Diseases.Advances in experimental medicine and biology · 2026
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  15. Elimination of oral foci of infection might lead to clinical improvement of Graves' orbitopathy.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025
    Article
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37 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Jôice Dias CorrêaFaculty of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Débora Cerqueira CalderaroUniversity Hospital, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Gilda Aparecida FerreiraUniversity Hospital, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Santuza Maria Souza MendonçaFaculty of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Gabriel R FernandesRené Rachou Research Center, Oswaldo Cruz Foundation, Belo Horizonte, Minas Gerais, Brazil.
E XiaoPenn Dental School, University of Pennsylvania, Philadelphia, PA, USA.
Antônio Lúcio TeixeiraUniversity Hospital, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Eugene J LeysCollege of Dentistry, The Ohio State University, Columbus, OH, USA.
Dana T GravesPenn Dental School, University of Pennsylvania, Philadelphia, PA, USA.
Tarcília Aparecida SilvaFaculty of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. silva.tarcilia@gmail.com.
Universidade Federal de Minas Gerais · BRUniversity of Pennsylvania · USFundação Oswaldo Cruz · BRThe Ohio State University · US

Funding

Diabetes-enhanced Experimental PeriodontitisR01DE017732 · NIDCR · UNIV OF MED/DENT OF NJ-NJ DENTAL SCHOOL · PI DANA T GRAVES · 2007 to 2026
$6.5M
Dendritic Cells and Periodontal DiseaseR01DE021921 · NIDCR · UNIVERSITY OF PENNSYLVANIA · PI GRAVES, DANA T · 2012 to 2022
$4.2M
NIDCR NIH HHS R01 DE017732NIDCR NIH HHS R01 DE021921
6 · The paper itself

Abstract

backgroundPeriodontitis results from the interaction between a subgingival biofilm and host immune response. Changes in biofilm composition are thought to disrupt homeostasis between the host and subgingival bacteria resulting in periodontal damage. Chronic systemic inflammatory disorders have been shown to affect the subgingival microbiota and clinical periodontal status. However, this relationship has not been examined in subjects with systemic lupus erythematosus (SLE). The objective of our study was to investigate the influence of SLE on the subgingival microbiota and its connection with periodontal disease and SLE activity.

methodsWe evaluated 52 patients with SLE compared to 52 subjects without SLE (control group). Subjects were classified as without periodontitis and with periodontitis. Oral microbiota composition was assessed by amplifying the V4 region of 16S rRNA gene from subgingival dental plaque DNA extracts. These amplicons were examined by Illumina MiSeq sequencing.

resultsSLE patients exhibited higher prevalence of periodontitis which occurred at a younger age compared to subjects of the control group. More severe forms of periodontitis were found in SLE subjects that had higher bacterial loads and decreased microbial diversity. Bacterial species frequently detected in periodontal disease were observed in higher proportions in SLE patients, even in periodontal healthy sites such as Fretibacterium, Prevotella nigrescens, and Selenomonas. Changes in the oral microbiota were linked to increased local inflammation, as demonstrated by higher concentrations of IL-6, IL-17, and IL-33 in SLE patients with periodontitis.

conclusionsSLE is associated with differences in the composition of the microbiota, independently of periodontal status.

Indexed as

DysbiosisMicrobiotaAdultBacteriaBacteroidesDental PlaqueFemaleGingivaHigh-Throughput Nucleotide SequencingHumansInterleukin-17Interleukin-33Interleukin-6Lupus Erythematosus, SystemicMaleMiddle AgedIL17A protein, humanIL33 protein, humanInterleukin-17Interleukin-33Interleukin-6RNA, Ribosomal, 16SCytokineIllumina sequencingLupusOral microbiotaPeriodontitisSubgingival dental plaque

Identifiers

PMID28320468
PMCPMC5359961
OpenAlexW2601011344

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.