ArticleDaru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences2017
Thiolation of arabinoxylan and its application in the fabrication of controlled release mucoadhesive oral films.
Article in Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 48 citations in OpenAlex.
- Review
- Recent Advances in Biomedical Applications of Mannans and Xylans.Current drug targets · 2024Review
- Statistically Optimized Polymeric Buccal Films of Eletriptan Hydrobromide and Itopride Hydrochloride: An In Vivo Pharmacokinetic Study.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Patches as Polymeric Systems for Improved Delivery of Topical Corticosteroids: Advances and Future Perspectives.International journal of molecular sciences · 2022Review
- Article
- An Insight into Preparatory Methods and Characterization of Orodispersible Film-A Review.Pharmaceuticals (Basel, Switzerland) · 2022Review
- Improved Bioavailability of Ebastine through Development of Transfersomal Oral Films.Pharmaceutics · 2021Article
- Synthesis and Evaluation of Thiol-Conjugated Poloxamer and Its Pharmaceutical Applications.Pharmaceutics · 2021Article
- Thiolation of Biopolymers for Developing Drug Delivery Systems with Enhanced Mechanical and Mucoadhesive Properties: A Review.Polymers · 2020Review
- Drug Release Profiles and Disintegration Properties of Pectin Films.Materials (Basel, Switzerland) · 2019Article
- Prediction of Aqueous pACS omega · 2018Article
- Development of Tizanidine HCl-Meloxicam loaded mucoadhesive buccal films: In-vitro and in-vivo evaluation.PloS one · 2018Article
- Ferulated Arabinoxylans and Their Gels: Functional Properties and Potential Application as Antioxidant and Anticancer Agent.Oxidative medicine and cellular longevity · 2018Review
- Application of quasi-emulsification and modified double emulsification techniques for formulation of tacrolimus microsponges.International journal of nanomedicine · 2018Article
- Fabrication of polyvinyl alcohol based fast dissolving oral strips of sumatriptan succinate and metoclopramide HCL.Science progressArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMucoadhesion is an important property that helps oral drug delivery system to remain attached with buccal mucosa and hence to improve the delivery of the drug. The current study was designed to achieve the thiol modification of Arabinoxylan (ARX) and to develop a mucoadhesive oral film for the improved delivery of tizanidine hydrochloride (TZN HCl).
methodSynthesis of thiolated arabinoxylan (TARX) was accomplished by esterification of ARX with thioglycolic acid (TGA). TARX was further used for the development of mucoadhesive oral films which were prepared by using a solvent casting technique. Formulation of the films was designed and optimized by using central composite design (CCRD), selecting TARX (X
resultsThiolation of ARX was confirmed by fourier transform infra-red spectroscopy (FTIR) as a peak related to thiol group appeared at 2516 cm
conclusionIn nutshell, TARX in combination with glycerolwas found to be suitable for the development of controlled release mucoadhesive oral films of TZN HCl. Schematic diagram showing conversion of ARX to TARX, TARX to oral film and evaluation of fabricated oral film.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.