SynthesisBMC pulmonary medicine2017
Systematic review of lung function and COPD with peripheral blood DNA methylation in population based studies.
Synthesis in BMC pulmonary medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The trial behind it
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Who cites it
19 citing papers in PubMed, 35 citations in OpenAlex.
- Epigenetic programming in bronchopulmonary dysplasia: a framework linking early-life exposures to persistent lung disease-a narrative review.Pediatric research · 2026Review
- Association of childhood BMI trajectory with post-adolescent and adult lung function is mediated by pre-adolescent DNA methylation.Respiratory research · 2022Article
- An epigenome-wide study of DNA methylation profiles and lung function among American Indians in the Strong Heart Study.Clinical epigenetics · 2022Article
- Chronic Obstructive Pulmonary Disease Is Associated with Epigenome-Wide Differential Methylation in BAL Lung Cells.American journal of respiratory cell and molecular biology · 2022Article
- Epigenetic Mechanisms in Parenchymal Lung Diseases: Bystanders or Therapeutic Targets?International journal of molecular sciences · 2022Review
- Does DNA methylation mediate the association of age at puberty with forced vital capacity or forced expiratory volume in 1 s?ERJ open research · 2022Article
- Sex-specific associations of asthma acquisition with changes in DNA methylation during adolescence.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2021Article
- Epigenome-wide association study on diffusing capacity of the lung.ERJ open research · 2021Article
- DNA Methylation-Based Age Prediction and Telomere Length Reveal an Accelerated Aging in Induced Sputum Cells Compared to Blood Leukocytes: A Pilot Study in COPD Patients.Frontiers in medicine · 2021Article
- Co-methylation analysis in lung tissue identifies pathways for fetal origins of COPD.The European respiratory journal · 2020Article
- Role of DNA methylation in the association of lung function with body mass index: a two-step epigenetic Mendelian randomisation study.BMC pulmonary medicine · 2020Article
- DNA Methylation: A Potential Biomarker of Chronic Obstructive Pulmonary Disease.Frontiers in cell and developmental biology · 2020Review
- Epigenome-wide association study of lung function level and its change.The European respiratory journal · 2019Article
- Epigenetic targets for lung diseases.EBioMedicine · 2019Article
- Identification of novel differentially methylated sites with potential as clinical predictors of impaired respiratory function and COPD.EBioMedicine · 2019Article
- Increased serum IL-17 and decreased serum IL-10 and IL-35 levels correlate with the progression of COPD.International journal of chronic obstructive pulmonary disease · 2018Article
- No association between DNA methylation and COPD in never and current smokers.BMJ open respiratory research · 2018Article
- Lung ageing and COPD: is there a role for ageing in abnormal tissue repair?European respiratory review : an official journal of the European Respiratory Society · 2017Review
- Tobacco-smoking induced GPR15-expressing T cells in blood do not indicate pulmonary damage.BMC pulmonary medicine · 2017Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEpigenetic variations in peripheral blood have potential as biomarkers for disease. This systematic review assesses the association of lung function and chronic obstructive pulmonary disease (COPD) with DNA methylation profiles in peripheral blood from population-based studies.
methodsOnline databases Medline, Embase, and Web of Science were searched. Google Scholar was searched to identify grey literature. After removing duplicate articles, 1155 articles were independently screened by two investigators. Peer reviewed reports on population-based studies that examined peripheral blood DNA methylation in participants with measured lung function (FEV1, FEV1/FVC ratio) or known COPD status were selected for full-text review. Six articles were suitable for inclusion. Information regarding study characteristics, designs, methodologies and conclusions was extracted. A narrative synthesis was performed based on published results.
resultsThree of the six articles assessed the association of COPD with DNA methylation, and two of these also included associations with lung function. Overall, five reports examined the association of lung function with DNA methylation profiles. Five of the six articles reported 'significant' results. However, no consistent CpG sites were identified across studies for COPD status or lung function values.
conclusionsDNA methylation patterns in peripheral blood from individuals with reduced lung function or COPD may be different to those in people with normal lung function. However, this systematic review did not find any consistent associations of lung function or COPD with differentially methylated CpG sites. Large studies with a longitudinal design to address reverse causality may prove a more fruitful area of research.
trial registrationPROSPERO 2016: CRD42016037352 .
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