ArticleBMC infectious diseases2017
Cytomegalovirus, Epstein-Barr virus and varicella zoster virus infection in the first two years of life: a cohort study in Bradford, UK.
Article in BMC infectious diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Equity in protection: bridging global data gaps for an EBV vaccine-a systematic review and meta-analysis.BMJ global health · 2025Pooled it
- Early-life infections and life course health and disease in the EU child cohort network.European journal of epidemiology · 2026Article
- Timing of Intrapartum Antibiotics at Caesarean Section and Risk of Asthma, Eczema and Allergic Rhinitis: Results From a Natural Experiment.BJOG : an international journal of obstetrics and gynaecology · 2026Article
- Cytomegalovirus seroprevalence and seroconversion in the Irish blood donor population.Epidemiology and infection · 2026Article
- Does cytomegalovirus infection increase the risk of tuberculosis in UK children?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Observational
- Long-term dynamics of cytomegalovirus-specific antibodies in a longitudinal cohort of children followed up for the first decade of life.Scientific reports · 2025Article
- Case Report: Toripalimab: a novel immune checkpoint inhibitor in advanced nasopharyngeal carcinoma and severe immune-related colitis.Frontiers in immunology · 2023Article
- Factors predicting amoxicillin prescribing in primary care among children: a cohort study.The British journal of general practice : the journal of the Royal College of General Practitioners · 2022Article
- Infections due to dysregulated immunity: an emerging complication of cancer immunotherapy.Thorax · 2022Review
- Pathogenesis of human cytomegalovirus in the immunocompromised host.Nature reviews. Microbiology · 2021Review
- CMV, EBV, JCV and BKV infection and outcome following kidney transplantation in children initiated on a corticosteroid-minimisation immunosuppressive regimen.Pediatric nephrology (Berlin, Germany) · 2021Article
- Respiratory syncytial virus in young children: community cohort study integrating serological surveys, questionnaire and electronic health records, Born in Bradford cohort, England, 2008 to 2013.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2021Article
- Childcare attendance and risk of infectious mononucleosis: A population-based Danish cohort study.PloS one · 2021Article
- Coronavirus disease 2019 as a syndemic.Reviews in medical virology · 2021Article
- Regulation of the human NK cell compartment by pathogens and vaccines.Clinical & translational immunology · 2021Review
- Factors associated with cytomegalovirus serostatus in young people in England: a cross-sectional study.BMC infectious diseases · 2020Article
- Review
- Age at cytomegalovirus, Epstein Barr virus and varicella zoster virus infection and risk of atopy: The Born in Bradford cohort, UK.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2019Article
- Modelling the dynamics of EBV transmission to inform a vaccine target product profile and future vaccination strategy.Scientific reports · 2019Article
- Article
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Authors and funding
6 authors.
Funding
Abstract
backgroundCytomegalovirus (CMV), Epstein Barr virus (EBV) and varicella-zoster virus (VZV) are common herpesviruses frequently acquired in childhood, which establish persistent, latent infection and are likely to impact the developing immune system. Little is known about the epidemiology of CMV and EBV infections in contemporary UK paediatric populations, particularly whether age at infection differs by ethnic group.
methodsChildren enrolled in the Born in Bradford Allergy and Infection Study had a blood sample taken and a questionnaire completed at 12 and 24 months of age. Ordered logistic regression quantified associations between ethnicity and other risk factors and age at CMV/EBV/VZV infection (<12 months, 12-24 months, uninfected at 24 months).
resultsPakistani children (n = 472) were more likely to be infected with CMV and EBV at a younger age than White British children (n = 391) (CMV: adjusted odds ratio (OR) 2.53, 95% confidence interval (CI) 1.47-4.33; EBV: adjusted OR 2.16, 95% CI 1.43-3.26). Conversely, Pakistani children had lower odds of being VZV infected in the second year than White British children (adjusted OR 0.57, 95% CI 0.33-0.97). There was a strong association between increasing birth order and later CMV infection in Pakistani children.
conclusionsWe report large differences in CMV and EBV incidence in the first 2 years between Pakistani and White British children born in Bradford, which cannot be explained by differences in risk factors for infection. Our data will inform the optimum schedule for future CMV and EBV vaccination programmes.
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