ArticleBMC evolutionary biology2017
Retention of duplicated long-wavelength opsins in mosquito lineages by positive selection and differential expression.
Article in BMC evolutionary biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 32 citations in OpenAlex.
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- Spectral preferences of mosquitos are altered by odors.The Journal of experimental biology · 2025Article
- Bioluminescence and environmental light drive the visual evolution of deep-sea shrimp (Oplophoroidea).Communications biology · 2025Article
- UnveilingFrontiers in cellular and infection microbiology · 2025Article
- Vision guides the twilight search for oviposition sites of the Asian tiger mosquito, Aedes albopictus.PLoS neglected tropical diseases · 2024Article
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- Opsin Gene Duplication in Lepidoptera: Retrotransposition, Sex Linkage, and Gene Expression.Molecular biology and evolution · 2023Article
- Insect opsins and evo-devo: what have we learned in 25 years?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- Opsin1 regulates light-evoked avoidance behavior in Aedes albopictus.BMC biology · 2022Article
- The olfactory gating of visual preferences to human skin and visible spectra in mosquitoes.Nature communications · 2022Article
- Transcriptomic analysis of resistance and short-term induction response to pyrethroids, in Anopheles coluzzii legs.BMC genomics · 2021Article
- Elimination of vision-guided target attraction in Aedes aegypti using CRISPR.Current biology : CB · 2021Article
- The diversity of opsins in Lake Baikal amphipods (Amphipoda: Gammaridae).BMC ecology and evolution · 2021Article
- The genome of the stable fly, Stomoxys calcitrans, reveals potential mechanisms underlying reproduction, host interactions, and novel targets for pest control.BMC biology · 2021Article
- Evolution of Phototransduction Genes in Lepidoptera.Genome biology and evolution · 2019Article
- Ultraviolet inflorescence cues enhance attractiveness of inflorescence odour to Culex pipiens mosquitoes.PloS one · 2019Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOpsins are light sensitive receptors associated with visual processes. Insects typically possess opsins that are stimulated by ultraviolet, short and long wavelength (LW) radiation. Six putative LW-sensitive opsins predicted in the yellow fever mosquito, Aedes aegypti and malaria mosquito, Anopheles gambiae, and eight in the southern house mosquito, Culex quinquefasciatus, suggest gene expansion in the Family Culicidae (mosquitoes) relative to other insects. Here we report the first detailed molecular and evolutionary analyses of LW opsins in three mosquito vectors, with a goal to understanding the molecular basis of opsin-mediated visual processes that could be exploited for mosquito control.
resultsTime of divergence estimates suggest that the mosquito LW opsins originated from 18 or 19 duplication events between 166.9/197.5 to 1.07/0.94 million years ago (MY) and that these likely occurred following the predicted divergence of the lineages Anophelinae and Culicinae 145-226 MY. Fitmodel analyses identified nine amino acid residues in the LW opsins that may be under positive selection. Of these, eight amino acids occur in the N and C termini and are shared among all three species, and one residue in TMIII was unique to culicine species. Alignment of 5' non-coding regions revealed potential Conserved Non-coding Sequences (CNS) and transcription factor binding sites (TFBS) in seven pairs of LW opsin paralogs.
conclusionsOur analyses suggest opsin gene duplication and residues possibly associated with spectral tuning of LW-sensitive photoreceptors. We explore two mechanisms - positive selection and differential expression mediated by regulatory units in CNS - that may have contributed to the retention of LW opsin genes in Culicinae and Anophelinae. We discuss the evolution of mosquito LW opsins in the context of major Earth events and possible adaptation of mosquitoes to LW-dominated photo environments, and implications for mosquito control strategies based on disrupting vision-mediated behaviors.
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