ArticlePharmaceutical biology2017
Antimalarial and antiplasmodial activity of husk extract and fractions of Zea mays.
Article in Pharmaceutical biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 33 citations in OpenAlex.
- Research on the Mechanism and Material Basis of Corn (Pharmaceuticals (Basel, Switzerland) · 2024Review
- Senna occidentalis (L.) Link root extract inhibits Plasmodium growth in vitro and in mice.BMC complementary medicine and therapies · 2023Article
- Article
- Exploring combined herbal extract-loaded phytoniosomes for antimalarial and antibacterial activity against methicillin-resistant3 Biotech · 2021Article
- Medicinal plants as a fight against murine blood-stage malaria.Saudi journal of biological sciences · 2021Review
- Article
- Antimalarial Activity ofEvidence-based complementary and alternative medicine : eCAM · 2020Article
- Exploring Antimalarial Herbal Plants across Communities in Uganda Based on Electronic Data.Evidence-based complementary and alternative medicine : eCAM · 2019Review
- In vitro antiplasmodial activity, cytotoxicity, and gas chromatography - flame ionization detector metabolites fingerprint of extracts and fractions from Tetrorchidium didymostemon.Journal of Ayurveda and integrative medicineArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextZea mays L. (Poacae) husk decoctions are traditionally used in the treatment of malaria by various tribes in Nigeria.
objectiveTo assess the antimalarial and antiplasmodial potentials of the husk extract and fractions on malaria parasites using in vivo and in vitro models. MATERIALS AND
methodsThe ethanol husk extract and fractions (187-748 mg/kg, p.o.) of Zea mays were investigated for antimalarial activity against Plasmodium berghei using rodent (mice) malaria models and in vitro activity against chloroquine sensitive (Pf 3D7) and resistant (Pf INDO) strains of Plasmodium falciparum using the SRBR green assay method. Median lethal dose and cytotoxic activities against HeLa and HEKS cells were also carried out. The GCMS analysis of the most active fraction was carried out.
resultsThe husk extract (187-748 mg/kg, p.o.) with LD DISCUSSION AND
conclusionThese results suggest that the husk extract/fractions of Zea mays possesses antimalarial and antiplasmodial activities and these justify its use in ethnomedicine to treat malaria infections.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.