Evidence map›Paper›PMID 28320224›Full record

SynthesisThe American journal of psychiatry2017

Identification of Common Neural Circuit Disruptions in Cognitive Control Across Psychiatric Disorders.

Lisa M McTeague, Julia Huemer, David M Carreon, Ying Jiang, Simon B Eickhoff, Amit Etkin

Open access · bronzeAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in The American journal of psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 292 papers, 25 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
292citing papers in PubMed, 25 pooled it
24.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

292 citing papers in PubMed, 25 syntheses or guidelines pooled it, 629 citations in OpenAlex.

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  9. Management of Anxiety in Parkinson's Disease.Movement disorders clinical practice · 2025
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232 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Lisa M McTeagueFrom the Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston; the Department of Psychiatry and Behavioral Sciences and Stanford Neurosciences Institute, Stanford University, Stanford, Calif.; VA Palo Alto Healthcare System and the Sierra Pacific Mental Illness, Research, Education, and Clinical Center (MIRECC), Palo Alto, Calif.; the Department of Child and Adolescent Psychiatry, Medical University of Vienna, Vienna; the Institute for Neuroscience and Medicine, Research Center Jülich, Jülich, Germany; the Institute for Clinical Neuroscience and Medical Psychology, Heinrich-Heine University Düsseldorf, and the Institute for Systems Neuroscience, School of Medicine, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany.
Julia HuemerFrom the Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston; the Department of Psychiatry and Behavioral Sciences and Stanford Neurosciences Institute, Stanford University, Stanford, Calif.; VA Palo Alto Healthcare System and the Sierra Pacific Mental Illness, Research, Education, and Clinical Center (MIRECC), Palo Alto, Calif.; the Department of Child and Adolescent Psychiatry, Medical University of Vienna, Vienna; the Institute for Neuroscience and Medicine, Research Center Jülich, Jülich, Germany; the Institute for Clinical Neuroscience and Medical Psychology, Heinrich-Heine University Düsseldorf, and the Institute for Systems Neuroscience, School of Medicine, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany.
David M CarreonFrom the Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston; the Department of Psychiatry and Behavioral Sciences and Stanford Neurosciences Institute, Stanford University, Stanford, Calif.; VA Palo Alto Healthcare System and the Sierra Pacific Mental Illness, Research, Education, and Clinical Center (MIRECC), Palo Alto, Calif.; the Department of Child and Adolescent Psychiatry, Medical University of Vienna, Vienna; the Institute for Neuroscience and Medicine, Research Center Jülich, Jülich, Germany; the Institute for Clinical Neuroscience and Medical Psychology, Heinrich-Heine University Düsseldorf, and the Institute for Systems Neuroscience, School of Medicine, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany.
Ying JiangFrom the Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston; the Department of Psychiatry and Behavioral Sciences and Stanford Neurosciences Institute, Stanford University, Stanford, Calif.; VA Palo Alto Healthcare System and the Sierra Pacific Mental Illness, Research, Education, and Clinical Center (MIRECC), Palo Alto, Calif.; the Department of Child and Adolescent Psychiatry, Medical University of Vienna, Vienna; the Institute for Neuroscience and Medicine, Research Center Jülich, Jülich, Germany; the Institute for Clinical Neuroscience and Medical Psychology, Heinrich-Heine University Düsseldorf, and the Institute for Systems Neuroscience, School of Medicine, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany.
Simon B EickhoffFrom the Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston; the Department of Psychiatry and Behavioral Sciences and Stanford Neurosciences Institute, Stanford University, Stanford, Calif.; VA Palo Alto Healthcare System and the Sierra Pacific Mental Illness, Research, Education, and Clinical Center (MIRECC), Palo Alto, Calif.; the Department of Child and Adolescent Psychiatry, Medical University of Vienna, Vienna; the Institute for Neuroscience and Medicine, Research Center Jülich, Jülich, Germany; the Institute for Clinical Neuroscience and Medical Psychology, Heinrich-Heine University Düsseldorf, and the Institute for Systems Neuroscience, School of Medicine, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany.
Amit EtkinFrom the Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston; the Department of Psychiatry and Behavioral Sciences and Stanford Neurosciences Institute, Stanford University, Stanford, Calif.; VA Palo Alto Healthcare System and the Sierra Pacific Mental Illness, Research, Education, and Clinical Center (MIRECC), Palo Alto, Calif.; the Department of Child and Adolescent Psychiatry, Medical University of Vienna, Vienna; the Institute for Neuroscience and Medicine, Research Center Jülich, Jülich, Germany; the Institute for Clinical Neuroscience and Medical Psychology, Heinrich-Heine University Düsseldorf, and the Institute for Systems Neuroscience, School of Medicine, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany.
VA Palo Alto Health Care System · US

Funding

Meta-anaylsis in human brain mappingR01MH074457 · NIMH · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI FOX, PETER THORNTON · 2006 to 2024
$10.5M
Remediating Emotion Deficits in PTSD: Probing and Modulating NeurocircuitsK23MH104849 · NIMH · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI MCTEAGUE, LISA M · 2014 to 2017
$746k
NIMH NIH HHS K23 MH104849NIMH NIH HHS R01 MH074457
6 · The paper itself

Abstract

objectiveCognitive deficits are a common feature of psychiatric disorders. The authors investigated the nature of disruptions in neural circuitry underlying cognitive control capacities across psychiatric disorders through a transdiagnostic neuroimaging meta-analysis.

methodA PubMed search was conducted for whole-brain functional neuroimaging articles published through June 2015 that compared activation in patients with axis I disorders and matched healthy control participants during cognitive control tasks. Tasks that probed performance or conflict monitoring, response inhibition or selection, set shifting, verbal fluency, and recognition or working memory were included. Activation likelihood estimation meta-analyses were conducted on peak voxel coordinates.

resultsThe 283 experiments submitted to meta-analysis included 5,728 control participants and 5,493 patients with various disorders (schizophrenia, bipolar or unipolar depression, anxiety disorders, and substance use disorders). Transdiagnostically abnormal activation was evident in the left prefrontal cortex as well as the anterior insula, the right ventrolateral prefrontal cortex, the right intraparietal sulcus, and the midcingulate/presupplementary motor area. Disruption was also observed in a more anterior cluster in the dorsal cingulate cortex, which overlapped with a network of structural perturbation that the authors previously reported in a transdiagnostic meta-analysis of gray matter volume.

conclusionsThese findings demonstrate a common pattern of disruption across major psychiatric disorders that parallels the "multiple-demand network" observed in intact cognition. This network interfaces with the anterior-cingulo-insular or "salience network" demonstrated to be transdiagnostically vulnerable to gray matter reduction. Thus, networks intrinsic to adaptive, flexible cognition are vulnerable to broad-spectrum psychopathology. Dysfunction in these networks may reflect an intermediate transdiagnostic phenotype, which could be leveraged to advance therapeutics.

Indexed as

BrainBrain MappingCognitive DysfunctionDominance, CerebralHumansMental DisordersNerve NetNeuropsychological TestsPsychometricsReference ValuesCognitionCognitive ControlfMRIMeta-analysisRDoCTransdiagnostic

Identifiers

PMID28320224
PMCPMC5543416
OpenAlexW2602886720

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.