ArticleJournal of the neurological sciences2017
Neurological complications after tuberculous meningitis in a multi-state cohort in the United States.
Article in Journal of the neurological sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 5 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 5 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- Prevalence, incidence, and case fatality of tuberculous meningitis in adults living with HIV: a systematic review and meta-analysis.BMC public health · 2024Pooled it
- Global Frequency and Clinical Features of Stroke in Patients With Tuberculous Meningitis: A Systematic Review.JAMA network open · 2022Pooled it
- Pooled it
- Ventriculoperitoneal shunt insertion in human immunodeficiency virus infected adults: a systematic review and meta-analysis.BMC neurology · 2020Pooled it
- Clinical features, outcomes and prognostic factors of tuberculous meningitis in adults worldwide: systematic review and meta-analysis.Journal of neurology · 2019Pooled it
- Challenges in conducting trials for pediatric tuberculous meningitis: lessons from the field.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2019Trial
- Risk Factors for Poor Neurological Outcomes at Discharge in Tuberculous Meningitis: Disease Severity, Host Factors, and Drug Therapy.Tropical medicine and infectious disease · 2026Article
- Clinical and social determinants of treatment outcomes in central nervous system tuberculosis in a high-resource setting: a retrospective cohort study.BMC infectious diseases · 2026Article
- Quantitative ASL Perfusion and Vessel Wall MRI in Tuberculous Meningitis: A Pre- and Post-Treatment Study.Journal of clinical medicine · 2026Article
- Neurological complication burden and in-hospital mortality in non-HIV tuberculous meningitis across the lifespan: a retrospective cohort study.Frontiers in medicine · 2026Article
- A retrospective study on unfavorable 28-day neurological outcomes of stage II TB meningitis.Scientific reports · 2025Article
- Mortality predictors and diagnostic challenges in adult tuberculous meningitis: a retrospective cohort of 100 patients.Tropical medicine and health · 2025Article
- Caudate Head Ischemic Stroke with Concurrent Tubercular Meningoencephalitis: A Case Report.Reports (MDPI) · 2025Article
- Influence of HIV co-infection on clinical presentation and disease outcome in hospitalized adults with tuberculous meningitis in Brazil: a nationwide observational study.Frontiers in public health · 2025Observational
- A Rare Case of Wolfram Syndrome Presenting With Tuberculous Meningitis: A Case Report.Clinical case reports · 2025Article
- Risk factors associated with post-tuberculosis sequelae: a systematic review and meta-analysis.EClinicalMedicine · 2024Article
- Acute ischemic stroke in tuberculous meningitis.Frontiers in public health · 2024Article
- Pediatric acute hydrocephalus developing after tubercular meningitis: a case report study.Annals of medicine and surgery (2012) · 2024Article
- The rare manifestations in tuberculous meningoencephalitis: a review of available literature.Annals of medicine · 2023Review
- Central Nervous System Tuberculosis: Risk Factors for Mortality in a Propensity Score-Matched Case-Control Study.Open forum infectious diseases · 2023Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
background and purposeTo assess the rate of neurological complications and mortality after tuberculous meningitis in the United States.
methodsThe authors performed a retrospective cohort study of all patients 18years or older hospitalized for tuberculous meningitis in California between 2005 and 2010, New York between 2006 and 2012, and Florida between 2005 and 2012. Outcomes of interest were mortality and the following neurological complications: stroke, seizure, hydrocephalus requiring a ventriculoperitoneal shunt, vision impairment, and hearing impairment. Kaplan-Meier survival statistics were used to assess the cumulative rate of neurological complications and death. Cox proportional hazards regression was used to compare rates of complications in patients with and without human immunodeficiency virus (HIV) after adjustment for comorbidities.
results806 patients with tuberculous meningitis were identified, among whom the cumulative rate of any complication or death was 55.4% (95% CI, 51.5-59.3%). More than two-thirds of complications occurred during the initial hospitalization for tuberculous meningitis. Individual neurological complications were not uncommon: the cumulative rate of stroke was 16.8% (95% CI, 14.0-20.0%), the rate of seizure was 18.8% (95% CI, 15.4-22.8%), and the rate of ventriculoperitoneal shunting was 8.4% (95% CI, 6.4-10.9%). Vision impairment occurred in 21.6% (95% CI, 18.5-25.1%) of patients and hearing impairment occurred in 6.8% (95% CI, 4.9-9.4%). The mortality rate was 21.5% (95% CI, 18.4-24.9%). Patients with HIV infection were not at increased risk of complications compared to patients without HIV (hazard ratio, 1.2; 95% CI, 0.9-1.6).
conclusionsTuberculous meningitis is associated with significant risk of neurological complications and death in the United States.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.