ArticleArthritis & rheumatology (Hoboken, N.J.)2017
Effects of Treadmill Exercise on Advanced Osteoarthritis Pain in Rats.
Article in Arthritis & rheumatology (Hoboken, N.J.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Benefits and Mechanisms of Exercise Training for Knee Osteoarthritis.Frontiers in physiology · 2021Pooled it
- Methylene blue restores NADJournal of orthopaedic translation · 2026Article
- Treadmill running modulates infrapatellar fat pad remodeling in osteoarthritic rats in an intensity-dependent manner.BMC sports science, medicine & rehabilitation · 2026Article
- Exercise as Osteoarthritis Treatment in Wistar Rats Promotes Frequency-Dependent Benefits.Biology · 2025Article
- Voluntary running improves synaptic degeneration of the anterior cingulate cortex in knee osteoarthritis.Molecular brain · 2025Article
- JP4-039 protects chondrocytes from ferroptosis to attenuate osteoarthritis progression by promoting Pink1/Parkin-dependent mitophagy.Journal of orthopaedic translation · 2025Article
- Low-intensity muscle contraction exercise reduces pain sensitivity by modulating peripheral pathology and spinal sensitization in end-stage knee osteoarthritis rats.Frontiers in pain research (Lausanne, Switzerland) · 2025Article
- Animal Models of Osteoarthritis: Updated Models and Outcome Measures 2016-2023.Regenerative engineering and translational medicine · 2024Article
- Effects of platelet-rich plasma combined with isometric quadriceps contraction on cartilage in a rat model of knee osteoarthritis.Regenerative therapy · 2024Article
- Age- and Sex-Dependent Effects of Moderate Exercise on Endogenous Pain Inhibition in Rats.Biomedicines · 2024Article
- Face and Predictive Validity of MI-RAT (International journal of molecular sciences · 2023Article
- Effect of Moderate Exercise on the Superficial Zone of Articular Cartilage in Age-Related Osteoarthritis.Diagnostics (Basel, Switzerland) · 2023Article
- Pathological Characteristics of Monosodium Iodoacetate-Induced Osteoarthritis in Rats.Tissue engineering and regenerative medicine · 2023Article
- Mechanotransduction pathways in articular chondrocytes and the emerging role of estrogen receptor-α.Bone research · 2023Review
- Effects of Immobilization and Swimming on the Progression of Osteoarthritis in Mice.International journal of molecular sciences · 2022Article
- Study on the Role of MicroRNA-214 in the Rehabilitation of Cartilage in Mice with Exercise-Induced Traumatic Osteoarthritis.Current issues in molecular biology · 2022Article
- Exercise for Osteoarthritis: A Literature Review of Pathology and Mechanism.Frontiers in aging neuroscience · 2022Review
- Physical therapy as a promising treatment for osteoarthritis: A narrative review.Frontiers in physiology · 2022Review
- Can we prevent chronic osteoarthritis pain? A view from the bench.Osteoarthritis and cartilage · 2021Article
- Moderate-intensity treadmill running relieves motion-induced post-traumatic osteoarthritis mice by up-regulating the expression of lncRNA H19.Biomedical engineering online · 2021Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveExercise is commonly recommended for patients with osteoarthritis (OA) pain. However, whether exercise is beneficial in ameliorating ongoing pain that is persistent, resistant to nonsteroidal antiinflammatory drugs (NSAIDs), and associated with advanced OA is unknown.
methodsRats treated with intraarticular (IA) monosodium iodoacetate (MIA) or saline underwent treadmill exercise or remained sedentary starting 10 days postinjection. Tactile sensory thresholds and weight bearing were assessed, followed by radiography at weekly intervals. After 4 weeks of exercise, ongoing pain was assessed using conditioned place preference (CPP) to IA or rostral ventromedial medulla (RVM)-administered lidocaine. The possible role of endogenous opioids in exercise-induced pain relief was examined by systemic administration of naloxone. Knee joints were collected for micro-computed tomography (micro-CT) analysis to examine pathologic changes to subchondral bone and metaphysis of the tibia.
resultsTreadmill exercise for 4 weeks reversed MIA-induced tactile hypersensitivity and weight asymmetry. Both IA and RVM lidocaine D35, administered post-MIA, induced CPP in sedentary but not exercised MIA-treated rats, indicating that exercise blocks MIA-induced ongoing pain. Naloxone reestablished weight asymmetry in MIA-treated rats undergoing exercise and induced conditioned place aversion, indicating that exercise-induced pain relief is dependent on endogenous opioids. Exercise did not alter radiographic evidence of OA. However, micro-CT analysis indicated that exercise did not block lateral subchondral bone loss or trabecular bone loss in the metaphysis, but did block MIA-induced medial bone loss.
conclusionThese findings support the conclusion that exercise induces pain relief in advanced, NSAID-resistant OA, likely through increased endogenous opioid signaling. In addition, treadmill exercise blocked MIA-induced bone loss in this model, indicating a potential bone-stabilizing effect of exercise on the OA joint.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.