Evidence map›Paper›PMID 28319389›Full record

ArticleJournal of natural products2017

Potential Antiosteoporotic Natural Product Lead Compounds That Inhibit 17β-Hydroxysteroid Dehydrogenase Type 2.

Anna Vuorinen, Roger T Engeli, Susanne Leugger, Fabio Bachmann, Muhammad Akram, Atanas G Atanasov, Birgit Waltenberger, Veronika Temml, Hermann Stuppner, Liselotte Krenn and 5 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of natural products, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. The GenusFrontiers in pharmacology · 2021
    Review
  4. Bioactive Molecules and Their Mechanisms of Action.Molecules (Basel, Switzerland) · 2019
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 5 countries.

Anna VuorinenDivision of Molecular & Systems Toxicology, University of Basel , Klingelbergstraße 50, 4056 Basel, Switzerland.
Roger T EngeliDivision of Molecular & Systems Toxicology, University of Basel , Klingelbergstraße 50, 4056 Basel, Switzerland.
Susanne LeuggerDivision of Molecular & Systems Toxicology, University of Basel , Klingelbergstraße 50, 4056 Basel, Switzerland.
Fabio BachmannDivision of Molecular & Systems Toxicology, University of Basel , Klingelbergstraße 50, 4056 Basel, Switzerland.
Muhammad Akram
Atanas G AtanasovDepartment of Pharmacognosy, University of Vienna , Althanstraße 14, 1090 Vienna, Austria.
Birgit Waltenberger
Veronika Temml
Hermann Stuppner
Liselotte KrennDepartment of Pharmacognosy, University of Vienna , Althanstraße 14, 1090 Vienna, Austria.
Sylvin B AtebaLaboratory of Animal Physiology, Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde I , P.O. Box 812, Yaounde, Cameroon.
Dieudonné NjamenLaboratory of Animal Physiology, Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde I , P.O. Box 812, Yaounde, Cameroon.
Rohan A DavisGriffith Institute for Drug Discovery, Griffith University , Brisbane, QLD 4111, Australia.
Alex OdermattDivision of Molecular & Systems Toxicology, University of Basel , Klingelbergstraße 50, 4056 Basel, Switzerland.
Daniela SchusterORCID 0000-0002-9933-8938
University of Basel · CHUniversität Innsbruck · ATUniversité de Yaoundé I · CMUniversity of Vienna · ATGriffith University · AU

Funding

Austrian Science Fund FWF P 25971Austrian Science Fund FWF P 26782
6 · The paper itself

Abstract

17β-Hydroxysteroid dehydrogenase type 2 (17β-HSD2) converts the active steroid hormones estradiol, testosterone, and 5α-dihydrotestosterone into their weakly active forms estrone, Δ

Indexed as

17-Hydroxysteroid DehydrogenasesBiological ProductsEnzyme InhibitorsEtiocholanoloneHumansModels, MolecularMolecular StructureStructure-Activity RelationshipTestosterone17-Hydroxysteroid Dehydrogenases3 (or 17)-beta-hydroxysteroid dehydrogenaseandrostane-3,17-dioneBiological ProductsEnzyme InhibitorsEtiocholanoloneTestosterone

Identifiers

PMID28319389
PMCPMC5411959
OpenAlexW2603688176

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.