ArticleMolecular ecology resources2017
Unbroken: RADseq remains a powerful tool for understanding the genetics of adaptation in natural populations.
Article in Molecular ecology resources, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
76 citing papers in PubMed, 1 synthesis or guideline pooled it, 244 citations in OpenAlex.
- Shortcomings of Phylogenetic Studies on Recent Radiated Insular Groups: A Meta-Analysis Using Cabo Verde Biodiversity.International journal of molecular sciences · 2019Pooled it
- Assessing differences among elasmobranch nurseries to aid conservation based on a genomics framework.Conservation biology : the journal of the Society for Conservation Biology · 2026Article
- Conservation genetics and genetic vulnerability of Craigia yunnanensis (Malvaceae), a relict plant species with extremely small populations from Southwest China.Annals of botany · 2026Article
- Patterns of Local Adaptation in the Northern Leopard Frog (Evolutionary applications · 2026Article
- Coral Genetic Structure in the Western Indian Ocean Mirrors Ocean Circulation and Thermal Stress History.Evolutionary applications · 2026Article
- Genomic Architecture of Inbreeding Depression Associated With Hatching Failure in an Endangered Parrot.Molecular ecology · 2026Article
- Missing or Mis-Telling the Story? Trade-Offs for Restriction-Site Associated Compared to Whole Genome Sequencing.Molecular ecology · 2026Article
- To Migrate or not to Migrate? Exploring the Genomic Basis of Partial Migratory Behavior in Bats.Genome biology and evolution · 2025Article
- Genomic and biogeographic patterns of endemic geckos in the Galapagos Islands reveal population structure and species delimitation on inhabited islands.Scientific reports · 2025Article
- Population genetics show that aphids (Hemiptera: Aphididae) are limited by summer host-plant distribution at the regional scale.Journal of insect science (Online) · 2025Article
- Genomic Signals of Local Adaptation Associated With Environmental Variables inEcology and evolution · 2025Article
- Evolutionarily distinct lineages of a migratory bird of prey show divergent responses to climate change.Nature communications · 2025Article
- The Genomic Signature and Transcriptional Response of Metal Tolerance in Brown Trout Inhabiting Metal-Polluted Rivers.Molecular ecology · 2025Article
- Endangered Pinto/Northern Abalone (Evolutionary applications · 2024Article
- Computational Genomics and Its Applications to Anthropological Questions.American journal of biological anthropology · 2024Review
- Article
- Seascape Genomics of the Smooth Hammerhead SharkEcology and evolution · 2024Article
- High Crimean-Congo hemorrhagic fever incidence linked to greater genetic diversity and differentiation in Hyalomma marginatum populations in Türkiye.Parasites & vectors · 2024Article
- Effects of inbreeding on reproductive success in endangered North Atlantic right whales.Royal Society open science · 2024Article
- Demographic history and genomic signatures of selection in a widespread vertebrate ectotherm.Molecular ecology · 2024Article
16 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Comment on
Authors and funding
6 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recently, Lowry et al. addressed the ability of RADseq approaches to detect loci under selection in genome scans. While the authors raise important considerations, such as accounting for the extent of linkage disequilibrium in a study system, we strongly disagree with their overall view of the ability of RADseq to inform our understanding of the genetic basis of adaptation. The family of RADseq protocols has radically improved the field of population genomics, expanding by several orders of magnitude the number of markers available while substantially reducing the cost per marker. Researchers whose goal is to identify regions of the genome under selection must consider the LD of the experimental system; however, there is no magical LD cutoff below which researchers should refuse to use RADseq. Lowry et al. further made two major arguments: a theoretical argument that modeled the likelihood of detecting selective sweeps with RAD markers, and gross summaries based on an anecdotal collection of RAD studies. Unfortunately, their simulations were off by two orders of magnitude in the worst case, while their anecdotes merely showed that it is possible to get widely divergent densities of RAD tags for any particular experiment, either by design or due to experimental efficacy. We strongly argue that RADseq remains a powerful and efficient approach that provides sufficient marker density for studying selection in many natural populations. Given limited resources, we argue that researchers should consider a wide range of trade-offs among genomic techniques, in light of their study question and the power of different techniques to answer it.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.