ArticleLasers in surgery and medicine2017
Intraoperative optical coherence tomography for soft tissue sarcoma differentiation and margin identification.
Article in Lasers in surgery and medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23 citing papers in PubMed, 36 citations in OpenAlex.
- Polarisation-Sensitive Optical Coherence Tomography for Surgical Margin Evaluation and Diagnosis of Excised Canine Cutaneous and Subcutaneous Tumours.Veterinary and comparative oncology · 2026Article
- Biophotonics in veterinary medicine: current clinical applications, translational challenges, and emerging opportunities.Frontiers in veterinary science · 2026Article
- Artificial Intelligence in Label-Free Optical Imaging Applications.Methods in molecular biology (Clifton, N.J.) · 2026Article
- A Comprehensive Review of Margin Identification Methods in Soft Tissue Sarcoma.Current oncology (Toronto, Ont.) · 2025Review
- Raman spectral band imaging for the diagnostics and classification of canine and feline cutaneous tumors.The veterinary quarterly · 2025Article
- Machine learning based diagnostics of veterinary cancer on ultrasound and optical imaging data.The veterinary quarterly · 2025Article
- Polarisation Sensitive Optical Coherence Tomography Image Characteristics for Gastrointestinal Tumours and Normal Tissues at Surgical Margins in Dogs.Veterinary and comparative oncology · 2025Article
- Differentiation of canine and feline neoplasms using multi-modal imaging and machine learning.Scientific reports · 2025Article
- Optical coherence tomography for surgical margin evaluation of excised canine cutaneous and subcutaneous tumours.Veterinary and comparative oncology · 2022Article
- Article
- Evaluating optical coherence tomography for surgical margin assessment of canine mammary tumours.Veterinary and comparative oncology · 2021Article
- Optical coherence tomography imaging of excised canine apocrine gland anal sac adenocarcinoma tumours.Veterinary and comparative oncology · 2021Article
- The feasibility and utility of optical coherence tomography directed histopathology for surgical margin assessment of canine mast cell tumours.Veterinary and comparative oncology · 2021Article
- Diagnostic accuracy of optical coherence tomography for assessing surgical margins of canine soft tissue sarcomas in observers of different specialties.Veterinary surgery : VS · 2021Article
- Near-infrared imaging and optical coherence tomography for intraoperative visualization of tumors.Veterinary surgery : VS · 2020Review
- Use of Intraoperative Radioguidance in Recurrent Merkel Carcinoma.Case reports in surgery · 2020Article
- Advanced Cancer Imaging Applied in the Comparative Setting.Frontiers in oncology · 2020Article
- Comparison between optical coherence tomographic and histopathologic appearances of artifacts caused by common surgical conditions and instrumentation.Veterinary surgery : VS · 2019Article
- Intra-operative imaging of surgical margins of canine soft tissue sarcoma using optical coherence tomography.Veterinary and comparative oncology · 2019Article
- Complementary use of polarization-sensitive and standard OCT metrics for enhanced intraoperative differentiation of breast cancer.Biomedical optics express · 2018Article
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11 authors at 1 institution in 1 country.
Funding
Abstract
BACKGROUND AND
objectiveSarcomas are rare but highly aggressive tumors, and local recurrence after surgical excision can occur in up to 50% cases. Therefore, there is a strong clinical need for accurate tissue differentiation and margin assessment to reduce incomplete resection and local recurrence. The purpose of this study was to investigate the use of optical coherence tomography (OCT) and a novel image texture-based processing algorithm to differentiate sarcoma from muscle and adipose tissue. STUDY DESIGN AND
methodsIn this study, tumor margin delineation in 19 feline and canine veterinary patients was achieved with intraoperative OCT to help validate tumor resection. While differentiation of lower-scattering adipose tissue from higher-scattering muscle and tumor tissue was relatively straightforward, it was more challenging to distinguish between dense highly scattering muscle and tumor tissue types based on scattering intensity and microstructural features alone. To improve tissue-type differentiation in a more objective and automated manner, three descriptive statistical metrics, namely the coefficient of variation (CV), standard deviation (STD), and Range, were implemented in a custom algorithm applied to the OCT images.
resultsOver 22,800 OCT images were collected intraoperatively from over 38 sites on 19 ex vivo tissue specimens removed during sarcoma surgeries. Following the generation of an initial set of OCT images correlated with standard hematoxylin and eosin-stained histopathology, over 760 images were subsequently used for automated analysis. Using texture-based image processing metrics, OCT images of sarcoma, muscle, and adipose tissue were all found to be statistically different from one another (P ≤ 0.001).
conclusionThese results demonstrate the potential of using intraoperative OCT, along with an automated tissue differentiation algorithm, as a guidance tool for soft tissue sarcoma margin delineation in the operating room. Lasers Surg. Med. 49:240-248, 2017. © 2017 Wiley Periodicals, Inc.
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