ArticlePloS one2017
Real-time monitoring of human blood-brain barrier disruption.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Strategies for Improved Intra-arterial Treatments Targeting Brain Tumors: a Systematic Review.Frontiers in oncology · 2020Pooled it
- Sleep alters neurovascular and hydrodynamic coupling in the human brain.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Structural Engineering of Tyrosine-Based Neuroprotective Peptides: A New Strategy for Efficient Blood-Brain Barrier Penetration.Foods (Basel, Switzerland) · 2025Article
- Immediate Irradiation Induced Cerebral Water and Hemodynamic Response in Whole Brain Radiotherapy.Annals of biomedical engineering · 2025Article
- Device-assisted strategies for drug delivery across the blood-brain barrier to treat glioblastoma.Communications materials · 2025Review
- Continuous Estimation of Blood Pressure by Utilizing Seismocardiogram Signal Features in Relation to Electrocardiogram.Biosensors · 2024Article
- Article
- Machine Learning Technology for EEG-Forecast of the Blood-Brain Barrier Leakage and the Activation of the Brain's Drainage System during Isoflurane Anesthesia.Biomolecules · 2023Article
- EEG biomarkers of activation of the lymphatic drainage system of the brain during sleep and opening of the blood-brain barrier.Computational and structural biotechnology journal · 2023Article
- Autoantibodies against NMDAR subunit NR1 disappear from blood upon anesthesia.Brain, behavior, & immunity - health · 2022Article
- A Historical Review of Brain Drug Delivery.Pharmaceutics · 2022Review
- Increased Direct Current-Electroencephalography Shifts During Induction of Anesthesia in Elderly Patients Developing Postoperative Delirium.Frontiers in aging neuroscience · 2022Article
- Challenges and opportunities to penetrate the blood-brain barrier for brain cancer therapy.Theranostics · 2022Review
- Focused Ultrasound Promotes the Delivery of Gastrodin and Enhances the Protective Effect on Dopaminergic Neurons in a Mouse Model of Parkinson's Disease.Frontiers in cellular neuroscience · 2022Article
- Modulating the Blood-Brain Barrier: A Comprehensive Review.Pharmaceutics · 2021Review
- Modified wavelet analysis of ECoG-pattern as promising tool for detection of the blood-brain barrier leakage.Scientific reports · 2021Article
- Brain Mechanisms of COVID-19-Sleep Disorders.International journal of molecular sciences · 2021Review
- Effects of intranasal guanosine administration on brain function in a rat model of ischemic stroke.Purinergic signalling · 2021Article
- A Destruction Model of the Vascular and Lymphatic Systems in the Emergence of Psychiatric Symptoms.Biology · 2021Review
- Mechanisms of Sound-Induced Opening of the Blood-Brain Barrier.Advances in experimental medicine and biology · 2021Article
Corrections and comments
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Authors and funding
16 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chemotherapy aided by opening of the blood-brain barrier with intra-arterial infusion of hyperosmolar mannitol improves the outcome in primary central nervous system lymphoma. Proper opening of the blood-brain barrier is crucial for the treatment, yet there are no means available for its real-time monitoring. The intact blood-brain barrier maintains a mV-level electrical potential difference between blood and brain tissue, giving rise to a measurable electrical signal at the scalp. Therefore, we used direct-current electroencephalography (DC-EEG) to characterize the spatiotemporal behavior of scalp-recorded slow electrical signals during blood-brain barrier opening. Nine anesthetized patients receiving chemotherapy were monitored continuously during 47 blood-brain barrier openings induced by carotid or vertebral artery mannitol infusion. Left or right carotid artery mannitol infusion generated a strongly lateralized DC-EEG response that began with a 2 min negative shift of up to 2000 μV followed by a positive shift lasting up to 20 min above the infused carotid artery territory, whereas contralateral responses were of opposite polarity. Vertebral artery mannitol infusion gave rise to a minimally lateralized and more uniformly distributed slow negative response with a posterior-frontal gradient. Simultaneously performed near-infrared spectroscopy detected a multiphasic response beginning with mannitol-bolus induced dilution of blood and ending in a prolonged increase in the oxy/deoxyhemoglobin ratio. The pronounced DC-EEG shifts are readily accounted for by opening and sealing of the blood-brain barrier. These data show that DC-EEG is a promising real-time monitoring tool for blood-brain barrier disruption augmented drug delivery.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.