ArticlePloS one2017
Toxicity effects of di-(2-ethylhexyl) phthalate to Eisenia fetida at enzyme, cellular and genetic levels.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 71 citations in OpenAlex.
- High-Volume Plasticizer di(2-Propylheptyl) Phthalate DPHP Induced Ecotoxic Effects in Aquatic and Terrestrial Arthropods.ACS environmental Au · 2026Article
- Earthworms under threat: assessing the environmental impact of cyhalofop-butyl herbicide on soil health and ecosystem sustainability.RSC advances · 2025Article
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- Nanoplastics: Status and Knowledge Gaps in the Finalization of Environmental Risk Assessments.Toxics · 2022Review
- Phthalate Esters Metabolic StrainMicroorganisms · 2022Article
- Toxicological effects of di-(2-ethylhexyl) phthalate in Gammarus pulex: a biochemical and histopathological assessment.Environmental science and pollution research international · 2021Article
- An integrative assessment to determine the sediment toxicity of Kaohsiung Harbor in Taiwan: combining chemical analysis and cytotoxicity assay.Environmental science and pollution research international · 2019Article
- Toxicity of phthalate esters to lettuce (Lactuca sativa) and the soil microbial community under different soil conditions.PloS one · 2018Article
- Article
- Potential effects of low molecular weight phthalate esters (CToxicology research · 2017Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Di-(2-ethylhexyl) phthalate (DEHP) is a dominant phthalic acid ester (PAE) that has aroused public concern due to its resistance to degradation and its toxicity as an endocrine-disrupting compound. Effects of different concentrations of DEHP on Eisenia fetida in spiked natural soil have been studied in the body of the earthworm by means of soil cultivation tests 7, 14, 21 and 28 days after exposure. The results indicated that, in general, superoxide dismutase (SOD) activity, malondialdehyde (MDA) content, metallothionein (MT) content, the expression of heat shock protein 70 (HSP 70) and all the tested geno-toxicity parameters are promoted as time elapses and with increasing concentration of DEHP. However, peroxidase (POD) activity, neutral red retention time (NRRT) and mitochondrial membrane potential difference values were found to decrease even at a low concentration of DEHP of 1 mg kg-1 soil (p<0.05). Clear toxic effects of DEHP on E. fetida have been generally recognized by means of the disturbance of antioxidant enzyme activity/content and critical proteins, cell membrane and organelle disorder and DNA damage estimated by length of tail, tail DNA ratio, and tail moment parameters. A concentration of DEHP of 3 mg kg-1 may be recommended as a precaution against the potential risk of PAEs in soils and for indicating suitable threshold values for other soil animals and soil micro-organisms.
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