Evidence map›Paper›PMID 28319084›Full record

ArticleNature microbiology2017

Structural and mechanistic insights into an archaeal DNA-guided Argonaute protein.

Sarah Willkomm, Christine A Oellig, Adrian Zander, Tobias Restle, Ronan Keegan, Dina Grohmann, Sabine Schneider

Abstract read
PubMed Publisher
In one paragraph

Article in Nature microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

74 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. A Mesophilic Argonaute fromBiomolecules · 2025
    Article
  11. Article
  12. An Engineered PfAgo with Wide Catalytic Temperature Range and Substrate Spectrum.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. MnChemical science · 2024
    Article

14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Sarah WillkommInstitute of Microbiology, University of Regensburg, 93053 Regensburg, Germany.
Christine A OelligCenter for Integrated Protein Science Munich CIPSM, Department of Chemistry, Technische Universität München, Lichtenbergstrasse 4, 85748 Garching, Germany.
Adrian ZanderInstitute of Microbiology, University of Regensburg, 93053 Regensburg, Germany.
Tobias RestleInstitute for Molecular Medicine, University of Lübeck, 23538 Lübeck, Germany.
Ronan KeeganCCP4, Research Complex at Harwell, Rutherford Appleton Laboratory, Harwell Oxford, Didcot OX11 0FA, UK.
Dina GrohmannInstitute of Microbiology, University of Regensburg, 93053 Regensburg, Germany.
Sabine SchneiderCenter for Integrated Protein Science Munich CIPSM, Department of Chemistry, Technische Universität München, Lichtenbergstrasse 4, 85748 Garching, Germany.

Funding

Biotechnology and Biological Sciences Research Council BB/H01330X/1Biotechnology and Biological Sciences Research Council BB/H013652/1
6 · The paper itself

Abstract

Argonaute (Ago) proteins in eukaryotes are known as key players in post-transcriptional gene silencing

Indexed as

Gene SilencingArgonaute ProteinsCrystallography, X-RayDNA, ArchaealHumansMethanocaldococcusModels, MolecularMutationProtein BindingProtein ConformationProtein FoldingRNA InterferenceAGO2 protein, humanArgonaute ProteinsDNA, Archaeal

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.