Trial reportClinical nutrition (Edinburgh, Scotland)2018
Protein intake distribution pattern does not affect anabolic response, lean body mass, muscle strength or function over 8 weeks in older adults: A randomized-controlled trial.
Trial report in Clinical nutrition (Edinburgh, Scotland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02787889 (Effect of Dietary Protein Intake Distribution on Protein Metabolism and Skeletal Muscle), which is not on this map. Cited by 38 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Dietary Protein Intake Distribution on Protein Metabolism and Skeletal Muscle
Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Evenness of dietary protein distribution is associated with higher muscle mass but not muscle strength or protein turnover in healthy adults: a systematic review.European journal of nutrition · 2021Pooled it
- Effect of 3 Different Daily Protein Intakes in a 2-Meal Eating Pattern on Protein Turnover in Middle Age and Older Adults: A Randomized Controlled Trial.The Journal of nutrition · 2025Trial
- Trial
- Muscle-Related Effect of Whey Protein and Vitamin DNutrients · 2022Trial
- Trial
- Metabolic Evaluation of the Dietary Guidelines' Ounce Equivalents of Protein Food Sources in Young Adults: A Randomized Controlled Trial.The Journal of nutrition · 2021Trial
- The impact of Hayward green kiwifruit on dietary protein digestion and protein metabolism.European journal of nutrition · 2021Trial
- Trial
- Anabolic response to essential amino acid plus whey protein composition is greater than whey protein alone in young healthy adults.Journal of the International Society of Sports Nutrition · 2020Trial
- Dietary protein intake is not associated with 5-y change in mid-thigh muscle cross-sectional area by computed tomography in older adults: the Health, Aging, and Body Composition (Health ABC) Study.The American journal of clinical nutrition · 2019Trial
- Distribution of daily protein intake and appendicular skeletal muscle mass in healthy free-living Chinese older adults.European journal of nutrition · 2024Article
- Dietary consumption of beef and red meat: a scoping review and evidence map on cognitive outcomes across the lifespan.Public health nutrition · 2023Article
- Anabolic Resistance in the Pathogenesis of Sarcopenia in the Elderly: Role of Nutrition and Exercise in Young and Old People.Nutrients · 2023Review
- Associations of protein intake, sources and distribution on muscle strength in community-dwelling older adults living in Auckland, New Zealand.Journal of nutritional science · 2023Article
- Tracing metabolic flux in vivo: basic model structures of tracer methodology.Experimental & molecular medicine · 2022Review
- Influences of Vitamin D and Iron Status on Skeletal Muscle Health: A Narrative Review.Nutrients · 2022Review
- Strategies to Prevent Sarcopenia in the Aging Process: Role of Protein Intake and Exercise.Nutrients · 2021Review
- Distribution of daily protein intake across meals and lower extremity functioning in community-dwelling Spanish older adults: a prospective cohort study.European journal of nutrition · 2021Article
- Comparison of basal whole-body protein kinetics and muscle protein synthesis between young and older adults.Physiological reports · 2020Article
- In Vivo and In Vitro Quantification of Glucose Kinetics: From Bedside to Bench.Endocrinology and metabolism (Seoul, Korea) · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
BACKGROUND &
aimsIn our recent acute metabolic study, we found no differences in the anabolic response to differing patterns of dietary protein intake. To confirm this in a chronic study, we investigated the effects of protein distribution pattern on functional outcomes and protein kinetics in older adults over 8 weeks.
methodsTo determine chronic effects of protein intake pattern at 1.1 g protein/kg/day in mixed meals on lean body mass (LBM), functional outcomes, whole body protein kinetics and muscle protein fractional synthesis rate (MPS) over 8-week respective dietary intervention, fourteen older subjects were randomly divided into either EVEN or UNVEN group. The UNEVEN group (n = 7) consumed the majority of dietary protein with dinner (UNEVEN, 15/20/65%; breakfast, lunch, dinner), while the EVEN group (n = 7) consumed dietary protein evenly throughout the day (EVEN: 33/33/33%).
resultsWe found no significant differences in LBM, muscle strength, and other functional outcomes between EVEN and UNEVEN before and after 8-week intervention. Consistent with these functional outcomes, we did not find significant differences in the 20-h integrated whole body protein kinetics [net protein balance (NB), protein synthesis (PS), and breakdown (PB)] above basal states and MPS between EVEN and UNEVEN intake patterns.
conclusionsWe conclude that over an 8-week intervention period, the protein intake distribution pattern in mixed meals does not play an important role in determining anabolic response, muscle strength, or functional outcomes. This trial is registered at https://ClinicalTrials.gov as NCT02787889.
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