ArticleKidney international2017
Early peritoneal dialysis reduces lung inflammation in mice with ischemic acute kidney injury.
Article in Kidney international, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 21 citations in OpenAlex.
- Organ Crosstalk During Injury: Mechanisms of Lung-Kidney Interaction in Critical Illness.Comprehensive Physiology · 2025Review
- Article
- Acute Kidney Injury and Acute Respiratory Distress Syndrome.Critical care clinics · 2021Review
- Lung metabolomics after ischemic acute kidney injury reveals increased oxidative stress, altered energy production, and ATP depletion.American journal of physiology. Lung cellular and molecular physiology · 2021Article
- Acute Kidney Injury in Hospitalized Children with COVID19.Journal of tropical pediatrics · 2021Article
- Peritoneal Dialysis Is an Option for Acute Kidney Injury Management in Patients with COVID-19.Blood purification · 2021Review
- Prophylactic Peritoneal Drainage is Associated with Improved Fluid Output after Congenital Heart Surgery.Pediatric cardiology · 2020Article
- IL-6-mediated hepatocyte production is the primary source of plasma and urine neutrophil gelatinase-associated lipocalin during acute kidney injury.Kidney international · 2020Article
- Article
- Distant Organ Dysfunction in Acute Kidney Injury: A Review.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2018Review
- Surgical Techniques for Catheter Placement and 5/6 Nephrectomy in Murine Models of Peritoneal Dialysis.Journal of visualized experiments : JoVE · 2018Article
Corrections and comments
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Authors and funding
15 authors at 1 institution in 2 countries.
Funding
Abstract
Although dialysis has been used in the care of patients with acute kidney injury (AKI) for over 50 years, very little is known about the potential benefits of uremic control on systemic complications of AKI. Since the mortality of AKI requiring renal replacement therapy (RRT) is greater than half in the intensive care unit, a better understanding of the potential of RRT to improve outcomes is urgently needed. Therefore, we sought to develop a technically feasible and reproducible model of RRT in a mouse model of AKI. Models of low- and high-dose peritoneal dialysis (PD) were developed and their effect on AKI, systemic inflammation, and lung injury after ischemic AKI was examined. High-dose PD had no effect on AKI, but effectively cleared serum IL-6, and dramatically reduced lung inflammation, while low-dose PD had no effect on any of these three outcomes. Both models of RRT using PD in AKI in mice reliably lowered urea in a dose-dependent fashion. Thus, use of these models of PD in mice with AKI has great potential to unravel the mechanisms by which RRT may improve the systemic complications that have led to increased mortality in AKI. In light of recent data demonstrating reduced serum IL-6 and improved outcomes with prophylactic PD in children, we believe that our results are highly clinically relevant.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.